鍖栧閿殑鎵撳紑鍜屽艦鎴愭槸鍙戠敓鍖栧鍙嶅簲鐨勫繀緇忚繃紼嬶紝縐戝瀹朵滑涔熷悜寰鑳藉鐩存帴鈥滅湅鍒扳濊繖浜涜繃紼嬨?br />
鏈榪戯紝浠ヨ嫃榛庝笘IBM鐮旂┒涓績縐戝瀹禠eo Gross涓洪鐨勭爺絀跺洟闃熶嬌鐢ㄦ壂鎻忛毀閬撴樉寰暅錛坰canning tunneling microscopy錛孲TM錛夎Е鍙戜竴涓崟鍒嗗瓙鍙嶅簲錛屽茍鐢ㄥ師瀛愬姏鏄懼井闀滐紙atomic force microscopy錛孉FM錛夊璇ュ垎瀛愯繘琛屽師瀛愭按騫充笂鐨勬垚鍍忥紝鍖呮嫭褰㈡垚鑷敱鍩轟腑闂翠綋鍜屾渶緇堜駭鍝佹椂鐨勭粏鑺傦紙Reversible Bergman cyclization by atomic manipulation. Nature Chemistry, 2016, DOI:10.1038/nchem.2438錛夈?br />
STM椹卞姩鐨勫弽搴旓紙涓嬶級鍙婂叾AFM鎴愬儚錛堜笂錛夈傚浘鐗囨潵婧愶細Nature Chemistry
璇ュ洟闃熺爺絀剁殑鏄竴縐嶉嗗悜鐨凚ergman鐜寲鍙嶅簲銆侭ergman鐜寲鍙嶅簲鍙戠幇浜?972騫達紝鐑簩鐐旓紙enediyne錛夊艦鎴愬弻鑷敱鍩轟腑闂翠綋錛岄殢鍚庡弻鑷敱鍩轟腑闂翠綋鑾峰彇涓や釜姘㈠艦鎴愮幆鍖栦駭鐗┿備竴浜涙姉鐧岃嵂鐗╋紝濡傚崱濂囬湁绱狅紙calicheamicin錛変篃鏄氳繃璇ュ弽搴斿垏鍓睤NA鑰岃搗鏁堛?br />
2013騫達紝鍔犲窞澶у浼厠鍒╁垎鏍＄殑Felix R. Fischer鍜孧ichael F. Crommie絳変漢鍒╃敤AFM瑙傚療鍒頒簡鐑簩鐐斾互鐩鎬技鐨勫弽搴旀満鐞嗙幆鍖栵紙Science, 2013, DOI: 10.1126/science.1238187錛夛紝鍦ㄨ繖欏瑰伐浣滀腑錛岀爺絀朵漢鍛橀氳繃鍔犵儹鍙嶅簲鍒嗗瓙浠ヤ績浣垮弽搴斿彂鐢熴?br />
鑰屽湪榪欓」鏂扮殑鐮旂┒涓紝Gross鍙婂叾鍚屼簨浣跨敤STM鎺㈤拡鐨勭數鍘嬭剦鍐茬巼鍏堟柇寮涓夌幆鍖栧悎鐗?,10-浜屾捍钂界殑絎竴涓狢-Br閿紝褰㈡垚鍗曡嚜鐢卞熀涓棿浣擄紝闅忓悗鍙堟柇寮絎簩涓狢-Br閿紝褰㈡垚鍙岃嚜鐢卞熀涓棿浣撱傝繖涓鍙嶅簲鍦∟aCl琛ㄩ潰涓婅繘琛岋紝鐩愯〃闈㈠彲浠ョǔ瀹氳嚜鐢卞熀錛屼粠鑰岃繘琛孉FM鎴愬儚銆傞殢鍚庝粬浠張鐢ㄥ彟涓涓數鍘嬭剦鍐插皢鍙岃嚜鐢卞熀涓棿浣撹漿鎹㈡垚鍙岀幆浜岀倲鍖栧悎鐗┿?br />
鏁翠釜榪囩▼鏄竴涓紑鐜嗗悜Bergman鍙嶅簲澶栧姞涓涓崟鑷敱鍩烘楠わ紝鍗曡嚜鐢卞熀姝ラ瀹為檯涓婂茍涓嶆槸Bergman鏈虹悊鐨勪竴閮ㄥ垎銆傜爺絀朵漢鍛樿繕璇佹槑浜嗚鍙嶅簲鏄彲閫嗙殑錛屼簩鐐旂儍鍖栧悎鐗╁彲浠ラ噸鏂板艦鎴愬弻鑷敱鍩轟腑闂翠綋銆?br />
鐮旂┒浜哄憳縐幫紝璇ユ妧鏈彲浠ヨ鍖栧瀹墮氳繃鍦ㄥ師瀛愭按騫充笂鎿嶆帶鍒嗗瓙鏉ュ紩鍙戣嚜鐢卞熀鍙嶅簲銆備粬浠寚鍑猴紝璇ユ柟娉曚笉浠呰兘浣挎柊鐨勫寲瀛﹀弽搴旀垚涓哄彲鑳斤紝鍚屾椂榪樻湁鍔╀簬緇勮鍙敤浜庡垎瀛愮數瀛愬櫒浠跺拰鍏跺畠搴旂敤鐨勫姛鑳藉垎瀛愩?br />
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