 | 濉戞枡 | 姍¤兌 | 綰ょ淮 | 娑傛枡涓庢補澧?/a> | 鑳剁矘鍓?/a> | 澶嶅悎鏉愭枡 | 鐭沖寲 | 鍖栧伐 | 浠櫒浠〃 | 鏂頒駭涓?/a> | 涓撻 | 榪斿洖棣栭〉 |
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| 濉戞枡 | 姍¤兌 | 綰ょ淮 | 娑傛枡涓庢補澧?/a> | 鑳剁矘鍓?/a> | 澶嶅悎鏉愭枡 | 鐭沖寲 | 鍖栧伐 | 浠櫒浠〃 | 鏂頒駭涓?/a> | 涓撻 | 榪斿洖棣栭〉 |
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鐩墠錛屾參鎬ф劅鏌撴т激鍙ｅ凡鎴愪負褰撳墠紺句細鏈涓ラ噸鐨勫獎鍝嶇ぞ浼氱粡嫻庡彂灞曞拰浜虹被鍋ュ悍鐨勪竴綾葷柧鐥呫傜洰鍓嶄復搴婁腑錛岄拡瀵規參鎬ф劅鏌撴т激鍙ｇ殑娌葷枟鎵嬫鏋佸叾鏈夐檺錛屼富瑕佸寘鎷崲鑽紙瀹氭湡鏇存崲娓呮磥鏁鋒枡錛夈佹墜鏈不鐤楋紙娓呭垱錛変互鍙婅礋鍘嬪惛寮曡緗紙VAC錛夛紙鍗沖皢鍏鋒湁璐熷帇鍚稿紩鍔熻兘鐨勬搗緇墊暦鏂欒鐩栦簬浼ゅ彛琛ㄩ潰錛屾寔緇礋鍘嬪惛寮曪紝鎸佺畫鍚稿嚭娓楀嚭娑插強鍧忔緇勭粐錛岃搗鍒版參鎬т激鍙ｄ慨澶嶇殑浣滅敤錛夈傛櫘閫氭崲鑽不鐤楀瓨鍦ㄦ不鐤楁晥鏋滃樊銆佸懆鏈熼暱銆佹偅鑰呯棝鑻︾瓑寮婄錛屾墜鏈不鐤椾互鍙婅礋鍘嬪惛寮曠瓑鏂瑰紡瀛樺湪緇忔祹鑺辮垂楂樸佺粍緇囨崯浼ゅぇ絳夐棶棰橈紝鍥犳錛屼復搴婁腑閽堝鎱㈡ф劅鏌撲激鍙ｏ紝浜熼渶涓縐嶈兘澶熼伩鍏嶄笂榪板姡鍔匡紝鍚屾椂鍙堝彲浠ユ湁鏁堟不鐤楁參鎬ф劅鏌撲激鍙ｇ殑鏂版柟娉曘?/span>
姘村嚌鑳剁殑鍑虹幇涓烘參鎬ф劅鏌撴т激鍙ｇ殑娌葷枟鎻愪緵浜嗘柊鐨勫疄鐜版柟妗堛傞殢鐫榪戝勾鏉ヤ漢浠姘村嚌鑳舵潗鏂欑殑娣卞叆浜嗚В錛岀幆澧冨埡嬋鍝嶅簲鍨嬫按鍑濊兌鎼澆鑽墿鎺ч噴緋葷粺涓轟笂榪伴渶姹傛彁渚涗簡鍙兘錛屼粬浠彲鍦ㄥ鐣屽埡嬋鍥犵礌錛堝娓╁害銆?/span>pH銆侀叾絳夛級浣滅敤涓嬶紝鑷彂鏀瑰彉鍏跺唴閮ㄧ粨鏋勶紝浠庤岃搗鍒版按鍑濊兌瑁傝В銆佺▼搴忔ф帶閲婅嵂鐗╃瓑浣滅敤銆?/span>
榪戞棩錛?/span>鍥涘窛澶у鍗庤タ鍖婚櫌楠ㄧ瀛旀竻娉夋暀鎺堝洟闃熷拰鍥涘窛澶у鍥藉鐢熺墿鍖誨鏉愭枡宸ョ▼鎶鏈爺絀朵腑蹇冧富浠?/span>/瀛﹂櫌瀛︽湳闄㈤暱鐜嬩簯鍏墊暀鎺堝洟闃?/span>錛屽湪ACS Applied Materials&Interfaces錛?/span>IF 9.226錛変笂鍙戣〃浜嗛涓猴細鈥?/span>Inflammation-Responsive Drug-Loaded Hydrogels with Sequential Hemostasis, Antibacterial, and Anti-Inflammatory Behavior for Chronically Infected Diabetic Wound Treatment鈥?/span>鐨勮鏂囥傛湰鏂囧皢綰ぉ鐒剁敓鐗╂潗鏂欐槑鑳墮氳繃鎺ユ灊鑻〖閰告敼鎬э紝鍒╃敤紜奸吀閰殑鍙屽搷搴旂壒鎬ф瀯寤哄叿鏈?/span>ROS銆?/span>pH鍝嶅簲鍨嬪彲娉ㄥ皠姘村嚌鑳訛紝鍚屾椂鎼澆杞借嵂綰崇背鑳舵潫鍜岄摱綰崇背綈囧鍚堜綋銆傞氳繃鎱㈡ф劅鏌撴т激鍙ｄ綆pH鍙婇珮ROS鐨勭壒孌婄敓鐞嗙幆澧冿紝璇ユ按鍑濊兌浣撶郴鍏鋒湁紼嬪簭鎬ф琛銆佹姉鑿屻佹姉鐐庣殑浼樿壇鐗規с?/span>
鏈枃瑕佺偣
1. 鏈爺絀墮氳繃鍏變環鎺ユ灊3緹у熀鑻〖閰稿垎瀛愪簬鏄庤兌渚ч摼錛屽茍涓庡叿鏈夐偦浣嶇緹鍩洪暱閾懼垎瀛愶紙PVA錛夊湪涓х幆澧冧笅閫氳繃鍔ㄦ佺〖閰擱叝閿氦鑱旀垚鑳訛紝鍚屾椂瑁呰澆鍏鋒湁pH鍝嶅簲鎬ц兘鐨勮澆灝肩編鑸掑埄(NIM)綰崇背鑳舵潫錛?/span>MIC@NIM錛夛紝鍙婂寘瑁?/span>涓囧彜闇夌礌(VAN)鐨勯摱綰崇背綈囪秴寮烘姉鑿岀矑瀛愶紙VAN-AgNCs錛夈傚湪鎱㈡ф劅鏌撲激鍙ｄ腑棣栧厛閲婃斁VAN-AgNCs鍗沖埢瓚呭己鎶楄弻錛屽悗鏍規嵁涓嶅悓pH鍥犲湴鍒跺疁鐨勯噴鏀炬姉鐐庤嵂鐗╋紝搴忚瘡鎬х殑鍙戞尌姝㈣銆佹姉鑿屻佹姉鐐庝綔鐢紝鏈緇堝疄鐜板姞閫熸參鎬т激鍙ｆ剤鍚堛?/span>
2. 鍙敞灝勭値鐥囧搷搴斿瀷姘村嚌鑳跺強鍙屼翰鍒嗗瓙鐨勫悎鎴愬拰鍒跺銆傝澆鑽兌鏉?/span>MIC@NIM銆?/span>VAN-AgNCs鐨勭悊鍖栬〃寰佺粨鏋溿?/span>
3.瀹為獙緇撴灉琛ㄦ槑鍙敞灝?/span>Gel-BA/PVA姘村嚌鑳跺叿鏈夋瀬浣崇殑鍙敞灝勬с佽嚜鎰堟ц兘浠ュ強紼沖畾鐨勫井瑙傜粨鏋勫拰嫻佸彉灞炴с?/span>
4.姘村嚌鑳朵綋澶栫幆澧冨搷搴斿疄楠岃瘉瀹炵〖閰擱叝閿槸楂樺害渚濊禆pH鍜?/span>ROS鑰屾柇瑁傜殑鍔ㄦ佸叡浠烽敭錛岃繖姝ｇ鍚堟參鎬ф劅鏌撲激鍙ｇ殑浣?/span>pH鍜岄珮ROS鐨勭梾鐞嗙壒鎬с傚洜姝や綋澶栬嵂鐗╅噴鏀懼疄楠屽彂鐜幫紝鎶楄弻鎴愬垎AgNCs鍙?/span>VAN鍙互榪呴熼噴鏀懼茍杈懼埌鏈楂樻祿搴︼紝鑰屾姉鐐庤嵂鐗?/span>NIM閲婃斁紼嬪害緙撴參銆傝繖縐嶇悊鎯崇殑閲婃斁鏇茬嚎瀹炵幇浜嗗鎱㈡ф劅鏌撲激鍙ｇ殑鍏堟姉鑿屽悗鎶楃値鐨勭悊鎯蟲不鐤楁晥鏋溿?/span>
5.閫氳繃浣撳鍜屼綋鍐呮琛璇曢獙璇佸疄錛?/span>Gel-BA/PVA姘村嚌鑳剁敱浜?/span>RGD搴忓垪鍙婇潤鐢靛惛闄勭瓑浣滅敤錛屽叿鏈夊嚭鑹茬殑姝㈣鏁堟灉銆?/span>
6.浣撳鎶楄弻瀹為獙楠岃瘉鍙楀埌楦″熬閰掔枟娉曞惎鍙戠殑鎶楃敓绱?/span>-AgNCs澶嶅悎浣撳叿鏈夋瀬寮虹殑鏉鑿屾晥鏋滐紝VAN鐮村潖緇嗚弻緇嗚優澹佸茍鍏佽鏇村AgNCs榪涘叆緇嗚弻鍐呴儴鐮村潖DNA浠庤岃搗鍒板交搴曠殑鏉鑿屾晥鏋溿?/span>
7.閫氳繃浣撳婧惰瀹為獙銆佺粏鑳炵浉瀹規у強鍒掔棔瀹為獙絳夛紝楠岃瘉Gel-BA/PVA姘村嚌鑳跺叿鏈夎壇濂界殑鐢熺墿鐩稿鎬у茍鏈夋晥淇冭繘L929緇嗚優榪佺Щ銆?/span>
8.閫氳繃楠岃瘉杞借嵂姘村嚌鑳跺鐐庣棁鍒烘縺鍚庡法鍣粏鑳炵殑鎶楃値鏁堟灉錛屾垜浠彂鐜拌杞?/span>NIM鐨勬按鍑濊兌鍙互鏈夋晥鎻愰珮宸ㄥ櫖緇嗚優IL-10鐨勮〃杈懼拰鎶戝埗TNF-偽鐨勮〃杈撅紝浠庤岃搗鍒版姉鐐庝綔鐢ㄣ?/span>
9. 閫氳繃澶ч紶緋栧翱鐥呮參鎬т激鍙ｆā鍨嬬殑寤虹珛錛岄獙璇?/span>Gel-BA/PVA杞借嵂姘村嚌鑳跺彲浠ヤ粠姝㈣銆佹潃鑿屻佹姉鐐庣瓑涓嶅悓鏂歸潰紼嬪簭鎬х殑淇冭繘鎱㈡ф劅鏌撲激鍙ｇ殑鎰堝悎銆?/span>
榪欓」宸ヤ綔涓嶄粎涓轟復搴婁腑甯歌鐨勬參鎬ф劅鏌撲激鍙ｇ殑娌葷枟鎻愪緵浜嗘柊鎬濊礬錛屼篃鎷撳浜嗙幆澧冨搷搴斿瀷姘村嚌鑳剁殑鐢熺墿鍖誨搴旂敤娼滃姏銆?/span>
璁烘枃絎竴浣滆呬負鍥涘窛澶у鍗庤タ鍖婚櫌楠ㄧ鐜嬬帀涓繪不鍖誨笀錛屽叡鍚岀涓浣滆呬負鍥涘窛澶у鍗庤タ鍖婚櫌楠ㄧ鍗氬＋浼嶆ぐ錛岄氳浣滆呬負鍥涘窛澶у鍗庤タ鍖婚櫌楠ㄧ瀛旀竻娉夋暀鎺?/span>鍜屽浗瀹剁敓鐗╁尰瀛︽潗鏂欏伐紼嬫妧鏈爺絀朵腑蹇冧富浠?/span>/瀛﹂櫌瀛︽湳闄㈤暱鐜嬩簯鍏墊暀鎺堝洟闃熸垚鍛?/span>鑳℃垚銆?/span>
鍙傝冩枃鐚細
Yu Wang, Ye Wu, Linyu Long, Li Yang, Daihua Fu, Cheng Hu, Qingquan Kong, and Yunbing Wang. Inflammation-Responsive Drug-Loaded Hydrogels with Sequential Hemostasis, Antibacterial, and Anti-Inflammatory Behavior for Chronically Infected Diabetic Wound Treatment.2021 ACS Applied Materials & Interfaces. DOI: 10.1021/acsami.1c09889
浣滆呯畝浠?/span>
鐜嬬帀
鍥涘窛澶у鍗庤タ鍖婚櫌楠ㄧ錛屼富娌誨尰甯?璁插笀錛屽崥澹悗錛屽崥澹瘯涓氫簬鍥涘窛澶у鍗庤タ涓村簥鍖誨闄㈤縐戝銆傜洰鍓嶄富鎸佸洓宸濈渷縐戞妧鍘呴噸鐐圭爺鍙戦」鐩?欏癸紝鍥涘窛鐪佸崼鍋ュ縐戠爺欏圭洰1欏癸紝鍥涘窛澶у鍗庤タ鍖婚櫌鈥?·3·5宸ョ▼鈥濅氦鍙夊縐戝垱鏂伴」鐩?欏癸紝鍥涘窛澶у鍗庤タ鍖婚櫌浣忛櫌鍖誨笀縐戠爺鍩洪噾1欏癸紝浠ョ涓浣滆呭彂琛⊿CI璁烘枃7綃囷紝medline璁烘枃2綃囷紝涓枃鏍稿績1綃囷紝鎺堟潈鍙戞槑涓撳埄2欏癸紝瀹炵敤鏂板瀷鍙戞槑涓撳埄6欏廣傛媴浠誨洓宸濈渷鍖誨浼氶縐戜笓濮斾細寰垱瀛︾粍縐樹功錛屼腑鍥芥畫鐤句漢搴峰鍗忎細鑲綋孌嬬柧搴峰涓撲笟濮斿憳浼氶縐戜復搴婃暀鑲插緇勫鍛橈紝SICOT涓浗閮ㄦ暟瀛楅縐戜笓濮斾細濮斿憳銆傛媴浠匯婁腑鍥戒慨澶嶉噸寤哄縐戞潅蹇椼嬬涓灞婇潚騫寸紪濮斻?/span>
瀛旀竻娉?/span>
涓諱換鍖誨笀銆佹暀鎺堛佸崥澹敓瀵煎笀銆傚洓宸濆ぇ瀛﹀崕瑗垮尰闄㈤縐戯紝鐜板吋浠誨崕瑗垮尰闄㈣タ钘忔垚鍔炲垎闄㈤櫌闀褲佸厷濮斿壇涔﹁錛涘崕瑗垮尰闄⑩滈珮鍘熷仴搴瘋仈鍚堢爺絀舵墍鈥濆壇鎵闀褲傜幇浠誨洓宸濈渷鍖誨浼?鍖誨笀鍗忎細楠ㄧ涓撳浼氬父濮旓紱鍥涘窛鐪佸尰瀛︿細楠ㄧ涓撳浼氬井鍒涘緇勭粍闀匡紱鍥涘窛鐪佸尰甯堝崗浼氶縐戝尰甯堝垎浼氶縐戝井鍒涘緇勫壇緇勯暱錛涗腑鍗庡尰瀛︿細楠ㄧ鍒嗕細楠ㄥ悍澶嶄笓濮斾細濮斿憳錛涗腑鍥藉尰甯堝崗浼氶縐戝尰甯堝垎浼氳兏鑵版銆佽剨鏌辨劅鏌撳緇勫鍛樸備富鎸佸浗瀹惰嚜鐒剁瀛﹀熀閲戦」鐩?欏癸紝鍥涘窛鐪佺鎶鍘呴」鐩?欏癸紝瑗胯棌縐戞妧鍘呴」鐩?欏癸紝鍥涘窛澶у鍗庤タ鍖婚櫌鈥?·3·5宸ョ▼鈥濅氦鍙夊縐戦噸鐐歸」鐩?欏癸紱浣滀負鍓富緙栧嚭鐗堜笓钁?閮紝鍙傜紪涓撹憲銆佹暀鏉?0閮紝鍙戣〃璁烘枃70浣欑瘒錛屽叾涓璖CI璁烘枃30浣欑瘒錛岃幏澶氶」涓撳埄鎺堟潈銆備綔涓哄弬涓庝漢鑾峰緱鏁欒偛閮ㄧ鎶榪涙涓絳夊涓欏廣?/span>
鍥涘窛澶у鍥藉鐢熺墿鍖葷敤鏉愭枡宸ョ▼鐮旂┒涓績鐜嬩簯鍏?/strong>錛氭暀鎺堬紝鍗氬＋鐢熷甯堬紝鍥藉鐢熺墿鍖誨鏉愭枡宸ョ▼鎶鏈爺絀朵腑蹇冧富浠匯佷腑鍥界敓鐗╂潗鏂欏浼氬壇鐞嗕簨闀褲佺鎶閮ㄧ敓鐗╂潗鏂欏浗闄呬氦嫻佸悎浣滃熀鍦頒富浠匯佹暀鑲查儴緇勭粐鍐嶇敓鎬х敓鐗╂潗鏂欑瀛︿笌宸ョ▼鍒涙柊寮曟櫤鍩哄湴涓諱換錛屸滅櫨鍗冧竾浜烘墠宸ョ▼鈥濆浗瀹剁駭浜洪夛紝鈥滃崄涓変簲鈥濆浗瀹墮噸鐐圭爺鍙戣鍒掗甯佷腑鍥藉績鑴戣綆¤仈鐩熷壇鐞嗕簨闀褲佸浗瀹舵湁紿佸嚭璐＄尞涓潚騫翠笓瀹訛紝鍥介檯鐢熺墿鏉愭枡縐戝涓庡伐紼嬪浼氳仈鍚堜細Fellow銆傝繎騫存潵涓昏浠庝簨鐢ㄤ簬蹇冭剳琛綆＄柧鐥呫佺硸灝跨梾銆佺溂縐戠柧鐥呯瓑娌葷枟鐨勬柊鍨嬬敓鐗╁尰鐢ㄦ潗鏂欏拰寰垱妞?浠嬪叆鍖葷枟鍣ㄦ鐨勫熀紜鐮旂┒涓庝駭鍝佸簲鐢ㄥ紑鍙戙備富鎸佸紑鍙戜簡涓緋誨垪鍥藉唴銆佸浗闄呴鍒涚殑鍖葷枟鍣ㄦ浜у搧騫跺疄鐜板ぇ瑙勬ā涓村簥搴旂敤銆傚湪姝ゅ熀紜涓婏紝宸茬敵鎶ュ浗鍐呫佸浗闄呬笓鍒?00澶氶」錛屽浗鍐呭鏈熷垔鍙戣〃璁烘枃100澶氱瘒銆?/span>
璇鵑緇勪富欏碉細
https://www.x-mol.com/groups/wang_yunbing
鐩稿叧閾炬帴
https://doi.org/10.1021/acsami.1c09889