 | 濉戞枡 | 姍¤兌 | 綰ょ淮 | 娑傛枡涓庢補澧?/a> | 鑳剁矘鍓?/a> | 澶嶅悎鏉愭枡 | 鐭沖寲 | 鍖栧伐 | 浠櫒浠〃 | 鏂頒駭涓?/a> | 涓撻 | 榪斿洖棣栭〉 |
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| 濉戞枡 | 姍¤兌 | 綰ょ淮 | 娑傛枡涓庢補澧?/a> | 鑳剁矘鍓?/a> | 澶嶅悎鏉愭枡 | 鐭沖寲 | 鍖栧伐 | 浠櫒浠〃 | 鏂頒駭涓?/a> | 涓撻 | 榪斿洖棣栭〉 |
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鍒跺墏宸ヤ綔鑰呭埄鐢ㄨ偪鐦ゅ井鐜鍏鋒湁浣?/span>pH銆?/span>楂?/span>H2O2鍜岄珮琛ㄨ揪鐨勭壒寮傛у彈浣撶瓑鐗瑰緛錛屾瀯寤?/span>pH/H2O2鏁忔劅鍜岄拡瀵?/span>楂?/span>琛ㄨ揪鑲跨槫鐗瑰紓鎬у彈浣撶殑澶氬姛鑳界撼綾寵嵂鐗╅掗佸鉤鍙幫紝鏃ㄥ湪灝嗚嵂鐗╂湁鏁堥澏鍚戦掗佸埌鑲跨槫緇勭粐鎴栫粏鑳烇紝瀹炵幇鑲跨槫鐨勯澏鍚戞不鐤椼傛墜鎬т粙瀛旂綰崇背媯掓槸浠嬪瓟紜呮棤鏈烘潗鏂?/span>錛?/span>闄ゅ叿鏈夋棤鏈虹鏉愭枡鐨勫垰鎬ч鏋躲佽緝澶х殑姣旇緝闈㈢Н鍜屽瓟浣撶Н銆佸彲璋冭妭鐨勪粙瀛斿瓟閬撳拰琛ㄩ潰涓板瘜鐨勭閱囧熀絳変紭鐐瑰錛岃繕鎷ユ湁鎵嬫х壒寮傛у拰媯掔姸褰㈣矊鐨勬嫇鎵戝浼樺娍錛岀粡蹇呰鐨勫寲瀛︿慨楗板悗錛屽彲浠ュ疄鐜拌偪鐦ょ殑闈跺悜閫掗佸茍鐢ㄤ簬鑲跨槫鐨勬不鐤椼?/span>
榪戞棩錛?/span>娌堥槼鑽澶у鑽闄㈡潕涓夐福鏁欐巿璇鵑緇勫拰涓浗鍖葷澶у鏉庨工鐒惰棰樼粍鍦ㄣ?/span>ACS Applied Materials & Interfaces銆嬫湡鍒婁笂鍙戣〃浜嗛涓?/span>鈥?/span>pH/H2O2 Dual-Responsive Chiral Mesoporous Silica Nanorods Coated with a Biocompatible Active Targeting Ligand for Cancer Therapy鈥?span style="font-family:瀹嬩綋;">鐨勭爺絀舵ц鏂囥傛枃涓瀯寤虹殑閫掕嵂緋葷粺鏄湪琛ㄩ潰鏄撲簬鍔熻兘鍖栫殑媯掔姸浠嬪瓟紜呯撼綾崇矑鐨勫熀紜涓婏紝灝嗚嫰紜奸吀棰戝摢閱囬叝瀚佹帴鍒版鐘朵粙瀛旂綰崇背綺掕〃闈紝璧嬩簣浠嬪瓟紜呯撼綾蟲鐨勬墜鎬у拰瀵?/span>H2O2鐨勬晱鎰熸э紝鍐嶅皢鎶楃檶鑽樋闇夌礌杞藉叆綰崇背綺掑瓙鐨勫瓟閬撲腑錛岀劧鍚庡湪綺掑瓙琛ㄩ潰鍖呰９浜嗛忔槑璐ㄩ吀-鐜硦綺懼叡鑱氱墿浣滀負鈥?/span>瓚呭垎瀛愬紑鍏?/span>鈥?/span>錛屽嵆鍙槻姝㈤樋闇夌礌榪囨棭閲婃斁鍙堣兘鍙祴浜堢矑瀛愪富鍔ㄩ澏鍚戞с傝緋葷粺鏄竴縐嶅畨鍏ㄣ佹湁鏁堢殑pH/H2O2 鍙岄噸鏁忔劅媯掔姸鎵嬫т粙瀛旂綰崇背閫掗佸鉤鍙幫紝鍏鋒湁涓誨姩闈跺悜鍜?/span>pH/H2O2鍙岄噸鏁忔劅鐨勫閲嶆姉鐧屼紭鍔褲傜爺絀剁粨鏋滆瘉鏄庯紝杞戒綋涓殑闃塊湁绱犲湪浣?/span>pH鑲跨槫寰幆澧冧笅鍘熶綅閲婅嵂錛屽悓鏃惰兘澶熸彁楂樿偪鐦ゅ井鐜鐨?/span>H2O2嫻撳害錛屾彁楂樼矑瀛愬湪鑲跨槫閮ㄤ綅H2O2鐨勬晱鎰熺壒鎬э紝鍙戞尌楂樻晥鎶楃檶鐨勪綔鐢ㄣ傝鐮旂┒浠庣郴緇熸瀯寤恒佽瘎浠峰埌緇嗚優鍜屾暣浣撳姩鐗╁眰闈㈢殑緋誨垪鑽悊鑽晥鐮旂┒緇撴灉錛岃瘉鏄庤繖鏄埄鐢ㄨ偪鐦ゅ井鐜鐗瑰紓鎬ф瀯寤虹殑澶氬姛鑳芥棤鏈虹綰崇背鑽墿閫掗佸鉤鍙扮殑涓涓垚鍔熸渚嬶紝涓鴻偪鐦ら澏鍚戦掕嵂緋葷粺鐨勮璁′笌鏋勫緩鎻愪緵浜嗕竴涓柊鎬濊礬銆?/span>
紺烘剰鍥?/span>1. 錛?/span>A錛?/span>pH/H2O2 鍙岄噸鏁忔劅鎬?/span>HA-CD/DOX-PCMSRs鐨勫悎鎴愯礬寰勶紱錛?/span>B錛夐氳繃CD44鍙椾綋浠嬪鑲跨槫緇嗚優鍐呭寲HA-CD/DOX-PCMSRs鍜?/span>璇ョ矑瀛?/span>鍦?/span>pH/H2O2鍙岄噸鍒烘縺鍥犲瓙浣滅敤涓嬮噴鏀捐嵂鐗╃殑鏈哄埗銆?/span>
鏈枃瑕佺偣
鍥?/span>7. HA-CD/DOX-PCMSRs瀵?/span>4T1緇嗚優鑽風槫灝忛紶鐨勬姉鐧屼綔鐢ㄥ拰鐢熺墿瀹夊叏鎬ц瘎浼般傦紙A錛夋不鐤楁柟妗堬紱錛?/span>B錛夋暣涓不鐤楄繃紼嬬殑鑲跨槫鐢熼暱鏇茬嚎錛涳紙C錛夋不鐤楁湡闂磋嵎鐦ゅ皬榧犱綋閲嶇殑鍔ㄦ佸彉鍖栵紱錛?/span>D錛夊湪21澶╂不鐤楄繃紼嬩綘錛岀浣撹偪鐦ゅ拰騫沖潎鑲跨槫閲嶉噺鐨勫吀鍨嬪浘鐗囷紱錛?/span>F錛変笉鍚屾不鐤楃粍鑲跨槫緇勭粐鐨?/span>H&E鍜?/span>TUNEL鏌撹壊銆?/span>
鐩稿叧閾炬帴
https://doi.org/10.1021/acsami.1c08532