澶嶆棪澶у涓佸緩涓滄暀鎺堣棰樼粍銆夿ioact. Mater.銆嬶細(xì)鍑嗕笁緇寸粏鑳?yōu)鐮斀I跺鉤鍙扮殑鐮斿埗鍙?qiáng)缁嗚優(yōu)琛屼负鐮斀I?/span>
2022-01-27 鏉ユ簮:涓浗鑱氬悎鐗╃綉 鐐瑰嚮嬈?/span>
鍏抽敭璇嶏細(xì)鐢熺墿鏉愭枡
鍥?/span>1. 鏈爺絀剁殑鍩烘湰鎬濊礬銆?/span>(A) 緇嗚優(yōu)鍝嶅簲鍑嗕笁緇村姏瀛﹀埡嬋鐨勭ず鎰忓浘銆?/span>(B) 鍏鋒湁鎷撴墤寰粨鏋勭殑PDMS鑶滅殑鍒墮犲強(qiáng)緇勮銆?/span> 璇ュ井?huà)箒鎺ц姱鐗囧湴鍒跺瀛樺湪璇稿闅剧偣锛?xì)棣栧厛錛?/span>闇瑕佽繘琛屼袱嬈″鍑嗭紱鍏舵錛?/span>鍦ㄥ鍑嗕箣鍚庤繕瑕佺珛鍗寵繘琛岀瓑紱誨瓙浣撻敭鍚?/span>浠ュ厤澶辨椿錛?/span>姝ゅ錛岀鏅剁墖涓婄殑寰浘妗堥氬父闅句互瑙傚療娓呮錛屽鍔犱簡(jiǎn)瀵瑰噯闅懼害銆?/span>涓轟簡(jiǎn)瑙ｅ喅榪欎簺闂錛岀爺絀朵漢鍛樿璁″茍緇勮浜?jiǎn)涓縐嶆柊鍨嬬殑鑺墖蹇熷鍑嗕華錛堝浘2錛夈傚嚟鍊熻瀵瑰噯浠殑棰勫鍑嗙▼搴忓拰鏈夋晥瑙傚療鐨勪紭鐐癸紝鍦ㄧ瓑紱誨瓙琛ㄩ潰澶勭悊鍚庡彲鍦?/span>1鍒嗛挓鍐?/span>鍗沖彲瀹屾垚瀵瑰噯鍜岄敭鍚堛?/span>
鍥?/span>4 (A) 寰祦鎺?/span>鎷変幾緋葷粺銆?/span>(B) 涓嶅悓鎷変幾棰戠巼涓嬫媺浼?/span>鐜?/span>涓庡帇鍔涚殑鍏崇郴銆傜悊璁虹粨鏋滀唬琛ㄦ潵鑷湁闄愬厓鍒嗘瀽鐨勯潤(rùn)鎬佹媺浼?/span>鐜?/span>銆?/span>
鐮旂┒浜哄憳瀵圭粏鑳?yōu)鐨?/span>鈥滅被涓夌淮鈥濈姸鎬佽繘琛岃緇嗚〃寰佲斾嬌鐢ㄥ叡鑱氱劍鏄懼井闀滆幏鍙栧師濮嬬粏鑳?yōu)鐨勪笁缁存暟鎹侀氳繃涓夌淮閲嶆瀯鏉ユ暟瀛楀寲鏄劇ず緇嗚優(yōu)褰㈡侊紝騫朵嬌鐢ㄧ悆褰㈠害鏉ヤ及璁＄粏鑳?yōu)迮炵姸銆傚浘5A灞曠ず浜?jiǎn)閫氳繃鍏辮仛鐒︽樉寰暅鑾峰緱鐨勮崸鍏夎漿鏌撴椿緇嗚優(yōu)鐘舵併傜爺絀朵漢鍛樺彂鐜版嫇鎵戝井緇撴瀯鍙互鏄捐憲鍦版敼鍙樼粏鑳?yōu)迮炴侊細(xì)鍦?/span>S涓紝緇嗚優(yōu)鍙楀埌涓ユ牸綰︽潫錛屽洜姝ょ粏鑳?yōu)琛ㄩ潰绮椌p欙紙浣庣悆褰㈠害錛夛紱鍦?/span>L涓紝緇嗚優(yōu)鏉炬暎鍦伴粡闄勫湪寰簳鐨勫簳閮ㄥ拰渚у涓婏紝鍛堥摵灞曞艦鎬侊紙浣庣悆褰㈠害錛夛紱鑰屽湪M涓紝緇嗚優(yōu)閫傚害榛忛檮浜庡井浜曪紝鍥犳緇嗚優(yōu)瓚嬩簬鍦嗗艦錛堥珮鐞冨艦搴︼級(jí)錛?/span>F涓婄殑緇嗚優(yōu)鏄洓縐嶅熀鏉夸腑鏈騫沖潶鐨勶紙鐞冨艦搴︽渶浣庯級(jí)銆傜悆搴︽槸鐢ㄤ笁緇撮噸寤虹殑鏁板瓧淇℃伅璁＄畻鐨勩傜粏鑳?yōu)鐞冨害鐨劸l熻緇撴灉鍒嗗埆涓?/span>0.54錛?/span>S錛夈?/span>0.65錛?/span>M錛夈?/span>0.59錛?/span>L錛夊拰0.50錛?/span>F錛夈?/span>
鍥?/span>5. 寰煴涓?/span> RFP-hMSC 緇嗚優(yōu)鐨勪笁緇磋〃寰併?/span>(A) 涓夌寰簳闃靛垪 (S銆?/span>M 鍜?L)涓拰騫抽潰錛?/span>F錛変笂鐨勭粏鑳?yōu)迮炴併備粠宸﹀埌鍙崇殑鍥涜琛ㄧず鍥涚鍩烘澘鐨勭ず鎰忓浘銆佸叡鑱氱劍鏄懼井闀滃吀鍨嬬粨鏋溿佷笁緇撮噸鏋勭粨鏋溿佸噯涓夌淮緇嗚優(yōu)榛忛檮紺烘剰鍥俱傚湪鍏辮仛鐒﹀浘鐗囦腑錛岀孩鑹茶〃紺虹敤RFP鏍囪鐨勬椿緇嗚優(yōu)錛屾槑鍦鴻〃紺哄井鏌遍樀鍒椼?/span>(B) 緇嗚優(yōu)鐨勭悆搴?(n鈮?/span>80)銆?/span> 鍥?/span> 6A鏄劇ず浜?/span>鍦ㄥ驚鐜媺浼革紙1 Hz錛?/span>10%錛夋湡闂?/span>錛?/span>RFP-hMSC緇嗚優(yōu)鐨?/span>鎵╂暎鍜?/span>鍙栧悜鍙戠敓浜?/span>鏄捐憲鍙樺寲銆傚浘 6B 鍒?/span>鏄劇ず浜?/span>緇嗚優(yōu)閾哄睍鍜屽彇鍚?/span>闅忔椂闂村彉鍖栫殑緇熻鏁版嵁銆傚湪鎷変幾鐨?/span>0-2灝忔椂鍐咃紝緇嗚優(yōu)鍦?/span>S銆?/span>M鍜?/span>L闃靛垪涓殑閾哄睍鏅亶闄嶄綆錛?/span>鍑忓皯5-8%錛夛紝鑰屽湪騫抽潰錛?/span>F錛?/span>涓婁笉鏄庢樉錛堝噺灝?/span>~1%錛夈?/span>鍙錛?/span>涓浜涚粏鑳?/span>閫夋嫨浜?/span>鏀剁緝鎴愬渾褰㈠茍榛忛檮鍦ㄥ井鏌辯殑渚у涓婁互閬垮厤鐗╃悊鎵板姩銆傚湪2-10灝忔椂鍐咃紝緇嗚優(yōu)鐨勯摵灞?/span>杈懼埌紼蟲(chóng)侊紝閾哄睍鐜?/span>鍒嗗埆涓?/span>39% (S)銆?/span>58% (M)銆?/span>53% (L)鍜?/span>76% (F)銆?/span>
鍥?/span>6. RFP-hMSC緇嗚優(yōu)鍦ㄥ驚鐜媺浼歌繃紼嬩腑鐨?/span>閾哄睍鍜?/span>鍙栧悜銆?/span> (A)寰幆鎷変幾鍚庡井浜?/span>闃靛垪涓粏鑳?yōu)鐨勬槕志収鐗囥傚簳閮ㄧ殑鍙岀澶磋〃紺烘媺浼告柟鍚戙傝崸鍏夋ā寮忔嫻嬪甫鏈?/span>RFP錛堢孩鑹茶崸鍏夛級(jí)鏍囪鐨勬椿緇嗚優(yōu)錛?/span>鐩稿樊妯″紡瑙傚療寰煴闃靛垪錛?/span>鍥句腑鎵鏄劇ず鐨勬槸鍚堝茍鐨勫浘鍍忋?/span>錛?/span>B錛?/span>緇嗚優(yōu)鐨勮〃瑙?/span>閾哄睍鐜?/span>鍜?/span>搴忓弬閲忛殢鎷変幾鏃墮棿鍙樺寲鐨勭粨鏋滐紝鍏?/span>涓殑綰㈢嚎浠呯敤浜庤瑙夊紩瀵?/span>銆?/span>(C) 寰幆鎷変幾鐨?/span>浜岀淮鎴栧噯涓夌淮鏉愭枡寰幆澧冧腑緇嗚優(yōu)鐘舵佺殑紺烘剰鍥俱?/span> 鎷変幾淇?jī)鋴?/span>緇嗚優(yōu)榪佺Щ鍙戠敓鏍規(guī)湰鎬у彉鍖栥備粠鍥?/span>7錛?/span>涓婇儴錛夋樉紺虹殑鍗曠粏鑳?yōu)杩伩U昏建榪?/span>鍙互鐪嬪嚭錛屾媺浼告樉钁?/span>鏀瑰彉?shù)簡(jiǎn)缁嗚優(yōu)杩伩U?/span>妯″紡銆?/span>鍙鍦ㄦ媺浼歌繃紼嬩腑錛岀粏鑳?yōu)鎰熻鍒板己鐑堢?/span>鍔涘騫叉壈錛?/span>鑰?/span>涓轟簡(jiǎn)閬垮厤鎵板姩錛?/span>緇嗚優(yōu)閫夋嫨鍦?/span>鎷変幾鐨勫瀭鐩?/span>鏂瑰悜涓?/span>榪佺Щ銆傛澶栵紝鐮旂┒浜哄憳鐢ㄨ疆寤?/span>榪佺Щ閫熷害鍜屽潎鏂逛綅縐?/span> (MSD) 閲忓寲浜?jiǎn)缁嗚優(yōu)杩伩U?/span>銆?/span>杞粨榪佺Щ閫熷害鐢?/span>榪佺Щ闀垮害 ( l ) 闄や互榪佺Щ鏃墮棿 ( t )寰楀嚭錛堣瑙佸浘7宸︿笂瑙掔ず鎰忓浘錛?/span>錛?/span>
(1)
鍥?/span>10. hMSC銆?/span>HFF銆?/span>HUVEC 緇嗚優(yōu)鐨勭洿寰勶紙姣忕粍n 鈮?100錛夈傚浘鍍忔槸鍦ㄧ粏鑳?yōu)鎺タU嶅埌緇勭粐鍩瑰吇鏉?(TCP) 琛ㄩ潰20 鍒嗛挓鍚庢媿鎽勭殑銆傛墍鏈夌粏鑳?yōu)鐨勫ぇ灏忎粙浜?S 鍜?M 寰簳鐨勭洿寰勪箣闂淬?/span> 璇ョ爺絀?/span>璁捐騫舵垚鍔熷埗澶囦簡(jiǎn)鍏鋒湁鍙媺浼稿井緇撴瀯鐨勫井?huà)箒鎺ц姱鐗囧Q屽湪姝ゅ熀紜涓婃瀯寤轟簡(jiǎn)緇嗚優(yōu)鐨勫噯涓夌淮榛忛檮鐘舵佸茍榪涜寰幆鎷変幾鍒烘縺銆傜粏鑳?/span>鍦?/span>涓嶅悓寰?/span>浜?/span>闃靛垪涓殑寰幆鎷変幾浣垮緱緇嗚優(yōu)鍛堢幇涓嶅悓姘村鉤鐨勬墿鏁ｃ?/span>鍙栧悜銆佽縼縐婚熺巼鍜岃縼縐繪柟鍚戞с?/span>鑰?/span>琚仛鍚堢墿寰煴鍖呭洿鐨勪腑絳夊井浜曞紩鍙戜簡(jiǎn)鏈寮虹殑緇嗚優(yōu)鍙嶅簲銆傜爺絀朵漢鍛樿繕鐮旂┒浜?jiǎn)涓壙U嶇被鍨嬬殑緇嗚優(yōu)鍦?/span>浜岀淮銆佸噯涓夌淮鍜屼笁緇村井鐜涓殑琛ㄧ幇錛涚粨鏋滆瘉瀹炲噯涓夌淮寰幆澧?/span>浠嬩簬浜岀淮鍜屼笁緇?/span>寰幆澧?/span>錛?/span>鑰屼笖鍦ㄨ澶氭柟闈紝閫傚綋鐨勫噯涓夌淮緇嗚優(yōu)鍙互妯′豢涓夌淮寰幆澧冧腑鐨勭粏鑳?yōu)锛屽悓鏃?/span>鍙堣兘鍍忓湪浜岀淮涓婁竴鏍鋒柟渚垮湴瑙傚療銆傝鐮旂┒涓哄噯涓夌淮寰幆澧?/span>鐨?/span>緇嗚優(yōu)鎷変幾鎻愪緵浜?jiǎn)鏈変环鍊肩殑宸ュ叿錛屽茍鎻ず浜?jiǎn)鐢熺墿鏉愭枡鎷撴墤鐗瑰緛瀵咕l嗚優(yōu)鐨勫鏉傚獎(jiǎng)鍝嶏紝浠庤屼負(fù)涓嶅悓緇村害鐨?/span>緇嗚優(yōu)鐮旂┒寮杈熶簡(jiǎn)鏂伴斿緞銆?/span>
鍘熸枃閾炬帴
https://www.sciencedirect.com/science/article/pii/S2452199X2100582X
鍏嶈矗澹版槑錛氶儴鍒嗚祫鏂欐潵婧愪簬緗戠粶錛岃漿杞界殑鐩殑鍦ㄤ簬浼犻掓洿澶氫俊鎭強(qiáng)鍒嗕韓錛屽茍涓嶆剰鍛崇潃璧炲悓鍏惰鐐規(guī)垨璇佸疄鍏剁湡瀹炴э紝
涔熶笉鏋勬垚鍏朵粬寤鴻銆備粎鎻愪緵浜ゆ祦騫沖彴錛屼笉涓哄叾鐗堟潈璐熻矗銆傚娑夊強(qiáng)渚墊潈錛岃鑱旂郴鎴戜滑鍙?qiáng)鏃朵慨鏀规垨鍒犻櫎銆?br>閭錛歩nfo@polymer.cn
錛堣矗浠葷紪杈戯細(xì)sun錛?
(2)
(3)
