棣欐腐澶у浠誨拸鍗庨櫌澹洟闃?Angew: 鎶楄 紱誨瓙璋冩帶鐨勯搨(II)閰嶅悎鐗╄嚜緇勮鐢ㄤ簬浜氱粏鑳?yōu)鍣ㄧ殑鍙鍖枊個嫻?/span>
2022-10-10 鏉ユ簮:涓浗鑱氬悎鐗╃綉 鐐瑰嚮嬈?/span>
鍏抽敭璇嶏細(xì)Pt(II)閰嶅悎鐗?/a> 瓚呭垎瀛愯嚜緇勮 鍙鍖栨嫻?/a> 絳夐摼鐢熼暱鏈哄埗 浜氱粏鑳?yōu)鍣?/a>
騫抽潰鏂瑰艦鐨勯噾灞?/span>Pt(II)閰嶅悎鐗╁湪闈炲叡浠?/span>Pt···Pt鐩鎬簰浣滅敤鍙?/span>蟺-蟺鐩鎬簰浣滅敤鐨勯┍鍔ㄤ笅榪涜緇勮鐨勫悓鏃舵敼鍙樺垎瀛愬墠娌胯建閬撶殑鑳介噺錛屽鑷村叾涓板瘜鏄撳彉鐨勫厜瀛︽ц川銆傚洜姝わ紝鍙互閫氳繃瑁佸壀鏈夋満閰嶄綋銆佹敼鍙樻姉琛＄瀛愩佽皟鎺у垎瀛愮粍瑁呯殑寰幆澧冪瓑澶氱絳栫暐錛屽鍒嗗瓙闂寸殑浣滅敤鍔涜繘琛岃皟鎺э紝鏋勭瓚鍏鋒湁涓嶅悓灝哄鍜屽艦璨岀殑綰崇背鍙戝厜鑱氶泦浣撱傝縿浠婁負(fù)姝紝騫抽潰鍨?/span>Pt(II)閲戝睘閰嶅悎鐗╄嚜緇勮鏋勭瓚浜嗗ぇ閲忕殑瓚呭垎瀛愮粍瑁呮潗鏂欙紝鍖呮嫭錛氱撼綾崇嚎銆佺撼綾崇墖銆佺撼綾崇銆侀噾灞炲嚌鑳躲佹恫鏅剁瓑銆傝綾昏秴鍒嗗瓙鏉愭枡鍏鋒湁浼樺紓鐨勫厜瀛︺佸崐瀵間綋瀛︺佷紶鎰熺瓑鎬ц兘錛屽湪浼楀棰嗗煙鍏鋒湁閲嶈鐨勫簲鐢ㄥ墠鏅傜劧鑰岋紝瀵逛簬鍏鋒湁鐗瑰畾鍔熻兘閰嶅悎鐗╃殑綺懼噯鏋勭瓚浠嶉潰涓磋緝澶氶棶棰樸?/span>
鍩轟簬鍓嶆湡紓峰厜閲戝睘閾?/span>(II)閰嶅悎鐗╃粍瑁呬笌鍏夊鎬ц川鐮旂┒鐨勫熀紜錛屼換瑭犲崕闄㈠＋鍥㈤槦鍙戝睍浜嗕竴縐嶉槾紱誨瓙璋冩帶閾?/span>(II)閰嶅悎鐗╃粍瑁呯殑鏂規(guī)硶錛屽茍鍒╃敤鍏朵赴瀵岀殑鍏夊鎬ц川瀹炵幇浜嗗涓嶅悓鐘舵佺粏鑳?yōu)鐨勫彲瑙嗗寲妫嫻嬨?/span>
棣栧厛錛岃璁″悎鎴愮郴鍒楀叿鏈変笉鍚屾姉琛＄瀛?/span>(CF3SO3鈭?/span>錛?/span>PF6鈭?/span>錛?/span>ClO4鈭?/span>鍜?/span>BF4鈭?/span>)鐨勯槼紱誨瓙鍨嬮噾灞?/span>Pt(II)閰嶅悎鐗┿傝繘鑰屾敼鍙樻祿搴﹀拰婧跺墏閰嶆瘮錛屽疄鐜頒簡瀵歸噾灞?/span>Pt(II)閰嶅悎鐗╃殑瓚呭垎瀛愯嚜緇勮琛屼負(fù)鍜屽彂鍏夐鑹茬殑鍙帶璋冭妭銆傞氳繃鏀瑰彉鎶楄 紱誨瓙瀵?/span>闈炲叡浠?/span>Pt···Pt鐩鎬簰浣滅敤鍜?/span>蟺-蟺鍫嗙Н鐩鎬簰浣滅敤榪涜璋冩帶錛屽疄鐜頒簡綰崇背鑱氶泦浣撶殑緇撴瀯杞彉錛堢撼綾蟲銆佺撼綾崇銆佺撼綾崇幆錛夈傛繁鍏ョ爺絀舵俯搴︿緷璧栫殑鍏夎氨瀛︾粨鏋滆〃鏄庯紝榪欑被Pt(II)鍒嗗瓙鍦ㄧ粍瑁呰繃紼嬩腑閲囩敤浜嗙瓑閾劇敓闀挎満鍒躲?/span>
鍒╃敤閲戝睘Pt(II)閰嶅悎鐗╃殑鍗曞垎瀛愪綋鍜岃仛闆嗕綋鐨勬祿搴︺佹憾鍓備緷璧栫壒鎬э紝鑾峰緱浜嗕粠緇胯壊鍒扮孩鑹茬殑鍙垏鎹㈠彂鍏夋潗鏂欙紝鐢ㄤ簬緇嗚優(yōu)鎴愬儚鐨勭爺絀跺伐浣溿傜粨鏋滆〃鏄庯紝閲戝睘Pt(II)閰嶅悎鐗╁垎甯冨湪婧墮叾浣撳拰緇嗚優(yōu)鏍鎬簹緇嗚優(yōu)鍣ㄤ腑鐨勫畾浣嶅叿鏈夋祿搴︿緷璧栨э紝涓斿叿鏈変笉鍚屽彂鍏夐鑹茬殑緇嗚優(yōu)鎴愬儚鐗規(guī)с傝繖琛ㄦ槑璇ョ被鏉愭枡鍙簲鐢ㄤ簬浜氱粏鑳?yōu)鍣ㄥ尯鍒垚鍍忓Q屼害鍙湁鏁堝尯鍒椿緇嗚優(yōu)涓庢緇嗚優(yōu)錛岃繘涓姝ョ敤鏉ヨ拷韙粏鑳?yōu)鍧忔杩嚱E嬨傚洜姝わ紝閫氳繃璋冩帶閲戝睘Pt(II)閰嶅悎鐗╁湪浜氱粏鑳?yōu)鍣ㄤ腑鐨勫垎甯冨Q屼負(fù)闈跺悜媯嫻嬨佺粏鑳?yōu)鐢熺墿瀛﹀強(qiáng)鍒嗗瓙鐩镐簰浣滅敤鏈哄埗鎻愪緵浜嗕究鎹风殑鏂规硶銆?/span>
鍒╃敤閲戝睘Pt(II)閰嶅悎鐗╃殑鑷粍瑁呬笌鍏夊鐗規(guī)х殑絳栫暐錛岄氳繃閲戝睘Pt(II)閰嶅悎鐗╁垱鍒惰秴鍒嗗瓙緇勮浣撴潵瀹氫綅媯嫻嬫垨瀹氭ц瘑鍒簹緇嗚優(yōu)鍣紝鏈夋湜鐢ㄤ簬緇嗚優(yōu)鐨勫彲鍖哄垎鎴愬儚鍜岀敓鐗╂爣璁板簲鐢紝涓虹敓鐗╃粏鑳?yōu)鐨剫個嫻嬫彁渚涘揩鎹峰彲瑙嗙殑鏂規(guī)硶銆?/span>
璁烘枃淇℃伅
Supramolecular Assembly of Organoplatinum(II) Complexes for Subcellular Distribution and Cell Viability Monitoring with Differentiated ImagingBaoning Li, Yaping Wang, Michael Ho-Yeung Chan, Mei Pan, Yonguang Li,* Vivian Wing-Wah Yam*Angewandte Chemie International EditionDOI: 10.1002/anie.202210703
鍘熸枃閾炬帴
https://doi.org/10.1002/anie.202210703
鍏嶈矗澹版槑錛氶儴鍒嗚祫鏂欐潵婧愪簬緗戠粶錛岃漿杞界殑鐩殑鍦ㄤ簬浼犻掓洿澶氫俊鎭強(qiáng)鍒嗕韓錛屽茍涓嶆剰鍛崇潃璧炲悓鍏惰鐐規(guī)垨璇佸疄鍏剁湡瀹炴э紝
涔熶笉鏋勬垚鍏朵粬寤鴻銆備粎鎻愪緵浜ゆ祦騫沖彴錛屼笉涓哄叾鐗堟潈璐熻矗銆傚娑夊強(qiáng)渚墊潈錛岃鑱旂郴鎴戜滑鍙?qiáng)鏃朵慨鏀规垨鍒犻櫎銆?br>閭錛歩nfo@polymer.cn
錛堣矗浠葷紪杈戯細(xì)sun錛?
