ABSTRACT: Despite the advanced modern biotechniques,thrombosis and bacterial infection of biomedical devices remaincommon complications that are associated with morbidityand mortality. Most antifouling surfaces are in solid formand cannot simultaneously fulfill the requirements for antithrombosisand antibacterial efficacy. In this work, we presenta facile strategy to fabricate a slippery surface. This surfaceis created by combining photografting polymerization withosmotically driven wrinkling that can generate a coarse morphology,and followed by infusing with fluorocarbon liquid. The lubricant-infused wrinkling slippery surface can greatly preventprotein attachment, reduce platelet adhesion, and suppress thrombus formation in vitro. Furthermore, E. coli and S. aureusattachment on the slippery surfaces is reduced by ～98.8% and ～96.9% after 24 h incubation, relative to poly(styrene-bisobutylene-b-styrene) (SIBS) references. This slippery surface is biocompatible and has no toxicity to L929 cells. This surfacecoatingstrategy that effectively reduces thrombosis and the incidence of infection will greatly decrease healthcare costs.
KEYWORDS: poly(styrene-b-isobutylene-b-styrene) (SIBS), slippery surface, photografting polymerization, antifouling, antibacterial
