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2020-03-16 ï¿½ï¿½Ô´ï¿½ï¿½ï¿½ß·ï¿½ï¿½Ó¿Æ¼ï¿½

ï¿½D1. Design of silk sericin inspired ï¿½ï¿½-HS with low fouling and low foreign-body response. (a) Silkworm cocoons of Bombyx mori. (b) SEM image of natural silk that contains sericin outside and fibroin inside (Image adapted with permission from Hiroshima University). (c) Amino acid component of sericin contains 45% hydroxylic amino acid including 34% serine, which is the most abundant amino acid in sericin. (d) The design of low fouling and low FBR ï¿½ï¿½-HS composed of racemic ï¿½ï¿½-homoserine that is inspired by the abundant serine within sericin. (e) ï¿½ï¿½-HS materials effectively resist biofouling and foreign-body response.

ï¿½D2. ï¿½ï¿½-HS SAMs resist protein adsorption as well as cell, platelet, and microbe adhesion. SPR sensorgrams of protein solutions and serum flowing over the SAMs: (a) Fibrinogen (Fg, 340 kDa, pI 5.5) is a large, blood plasma protein that strongly adsorbs to hydrophobic surfaces that is commonly used as a model for sticky serum proteins. (b) Lysozyme (Lyz, 14 kDa, pI 11.0) is a small, positively charged protein often used as a model for electrostatic interactions of proteins with surfaces. (c) Bovine serum albumin (BSA, 66.4 kDa, pI 4.7) is the negatively charged and most abundant protein in the bovine plasma (ï¿½ï¿½65%). (d) 10% serum. (e) 100% serum, which comprises a large diversity of proteins and other biomolecules. (f) Challenge of the antifouling surfaces with Fg, Lyz, BSA, 10% serum, and serum sequentially. Fluorescence micrographs and SEM images of surface biofouling from cell and microbes: (g) Fibroblast cell. (h) Platelet. (i) C. albicans. (j) S. aureus. (k) P. aeruginosa. Quantitative analysis on surface attachment of: (l) Fibroblast cell. (m) Platelet, n.d. represents not detected. (n) C. albicans. (o) S. aureus. (p) P. aeruginosa.

ï¿½D3. Hydrogel synthesis and evaluation of FBR for hydrogels implanted in mice. (a) Synthesis and gelation of ï¿½ï¿½-HS precursor (ï¿½ï¿½-HSDA) polymers to generate hydrogels, which were implanted subcutaneously into the backs of C57BL/6 mice. (b) Histological analysis after 1 week of implantation: H&E, hematoxylin & eosin, nuclei were stained blue and the cell cytoplasm was stained pink; F4/80, macrophage marker stained in brown; M&T, Massonï¿½ï¿½s trichrome, collagen was stained in blue, nuclei was stained in black, and the cytoplasm was stained in red to evaluate collagen deposition. (c) Massonï¿½ï¿½s trichrome staining to evaluate collagen encapsulation (red arrows) and visualized blood vessels (black arrows) after implantation for 4 weeks. (d) Collagen density within 100 ï¿½ï¿½m (at 10-ï¿½ï¿½m steps) of the hydrogel-tissue interface after implantation for 4 weeks. (e) Visualization of blood vessels (red fluorescence), via immune-staining with the endothelial cells marker CD31, in tissues surrounding hydrogels after 4 weeks of implantation. (f) quantified blood vessel density in tissues surrounding hydrogels after 4 weeks of implantation. (g) Massonï¿½ï¿½s trichrome staining to evaluate collagen encapsulation (red arrows) after implantation for 3 months. *P<0.01; **P<0.001, using one-way ANOVA with Tukeyï¿½ï¿½s post-test.

ï¿½D 4. Molecular simulations exploring the mechanisms underlying ï¿½ï¿½-HS''s strong antifouling and anti-FBR performance. (a) Hydration free energy of OEG6 and ï¿½ï¿½-HS. (b) Radial distribution functions between water molecules and the atoms of ï¿½ï¿½-HS (the oxygen atoms in the hydroxyl and carbonyl groups, respectively, and the nitrogen atom). (c) Snapshot of ï¿½ï¿½-HS in aqueous solution, the hydrogen bonding waters near both the backbone amide groups and the side chain hydroxyl groups. (d) The average number of hydrogen bonds (HB) between the SAM and water molecules. (e) Distance between the protein (mass center) and the SAM surface of OEG6 and ï¿½ï¿½-HS. (f) Snapshot of lysozyme on the OEG6 and ï¿½ï¿½-HS SAM, with explicit water molecules.

Õ“ï¿½ï¿½æœ½ï¿½: https://onlinelibrary.wiley.com/doi/abs/10.1002/anie.202000416

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