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Figure 3. SEM images of (a) C4MS, (b) C6MS, (c) C8MS, (d) C10MS and (e) C12MS and the schematic diagrams (bar = 500 nm).

Figure 4. The glucose-responsive insulin-releasing mechanism.

Figure 5. (a, b) The hypoglycemia-avoiding performances of the anti-diabetes agents evaluated on healthy rats with (c) the statistical analysis. (d, e) The 8-h hyperglycemia-ameliorating and hypoglycemia-avoiding performances of the anti-diabetes agents evaluated on diabetic rats with (f) the statistical analysis. (g) The 14-h hyperglycemia-ameliorating and hypoglycemia-avoiding performances. The data of ��Diabetic control�� were shown as the means �� SD (n = 3). The data of ��Healthy control��, ��C6MS��, ��C8MS��, ��C10MS��, ��INS��, ��Det-INS��, ��INS(H) + Det-INS(L)�� and ��INS(L) + Det-INS(H)�� were shown as the means �� SD (n = 5). The statistical analyses were performed by two-tailed Student''s t-test. * P < 0.05 and ** P < 0.01.

Figure 6. (a) The MTT assays and live-dead cell staining assays for CnMSs (n = 6, 8 and 10, scale bar = 200 ��m). (b) The hemolysis tests for CnMS (n = 4, 6, 8, 10 and 12) and the routine blood test for C10MS. (c) The in vivo fluorescence test on diabetic rats by using Cy5-labeled C10MS. (d) Histological analyses of C10MS on hearts, livers, spleens, lungs, and kidneys (scale bar = 100 ��m). The data of MTT assays were shown as the means �� SD (n = 6). The data of hemolysis tests were shown as the means �� SD (n = 3). The data of the routine blood test were shown as the means �� SD (n = 4).

  Փ��朽ӣ�https://doi.org/10.1016/j.jconrel.2022.10.044