Facile fabrication of polyurethane microcapsules carriers for tracing cellular internalization and intracellular pH-triggered drug release
writer：Yuqing Niu, Florian J. Stadler, Jun Song, Siping Chen, Shiguo Chen*.
keywords：Intracellular drug release, Polyurethane, Microcapsules, Endo/lysosomes, pH-sensitive
source：期刊
specific source：Colloids and Surfaces B: Biointerfaces
Issue time：2017年
A tailor-made
traceable pH-sensitive drug delivery system based on polyurethane (PU)
microcapsuleswas fabricated using a facile double-emulsion method containing
3,3-dioctadecyloxacarbocyanine per-chlorate, doxorubicin (DOX) and sodium bicarbonate
(NaHCO3). When PU microcapsules were immersedin acidic media, NaHCO3could react
with the H+to quickly produce CO2bubbles to puncture the PU shell,resulting in
rapid release of DOX to promptly reach the intracellular drug therapeutic
threshold to killcancer cells in a short period. Confocal laser scanning
microscopic analysis showed that these traceablepH-sensitive drug carriers can
be easily internalized by BGC 823 and Hela cells, and the loaded DOX canquickly
release from PU microcapsules in the endo-/lysosomes to be mainly resided in
cell nuclei. Thistraceable pH-sensitive drug carrier can achieve on-demand
controlled release profiles for visualizationof cancer therapy. Thus, it is a
potential candidate for anticancer drug delivery system in advanced
cancertherapy.