Rapid hemostatic and mild polyurethane-urea foam wound dressing for promoting wound healing.
writer：Xiangyu Liu, Yuqing Niu, Shiguo Chen*.
keywords：Polyurethane-urea, Rapid hemostatic, Foam wound dressing, Histological assessment
source：期刊
specific source：Materials Science & Engineering C: Materials for Biological Applications
Issue time：2017年
A novel rapid
hemostatic and mild polyurethane-urea foam(PUUF)wound dressingwas prepared by
the particle leaching method and vacuum freeze-drying method using 4,
4-Methylenebis(cyclohexyl isocyanate), 4,4-diaminodicyclohexylmethane and poly
(ethylene glycol) as raw materials. And X-ray diffraction (XRD), tensile test,
differential scanning calorimetry (DSC) and thermogravimetry (TG) were used to
its crystallinity, stress and strain behavior, and thermal properties,
respectively. Platelet adhesion, fibrinogen adhesion and blood clotting were
performed to evaluate its hemostatic effect. And H&E staining and Masson
Trichrome staining were used to itswound healing efficacy. The results revealed
the pore size of PUUF is 50–130 μm, and its porosity is 71.01%. Porous PUUF
exhibited good water uptake that was benefit to adsorb abundant wound exudates
to build a regional moist environment beneficial for wound healing. The PUUF
wound dressing exhibit better blood coagulation effect than commercial
polyurethane dressing (CaduMedi). Though both PUUF and CaduMedi facilitated
wound healing generating full re-epithelialization within 13 days, PUUF was
milder and lead to more slight inflammatory response than CaduMedi. In
addition, PUUF wound dressing exhibited lower cytotoxicity than CaduMedi
against NIH3T3 cells. Overall, porous PUUF represents a novel mild wound
dressing with excellent water uptake, hemostatic effect and low toxicity, and
it can promote wound healing and enhance reepithelialization.