[ACS Appli. Mater. Interface] Tough and Biocompatible Hydrogels Based on in situ Interpenetrating Networks of Di-thiol-connected Graphene Oxide and Poly(vinyl alcohol)
writer：Gaolai Du, Lei Nie, Guorong Gao, Yuanna Sun, Ruixia Hou, Hua Zhang, Tao Chen, and Jun Fu*
keywords：inorganic/organic, IPN, tough, cell-adhesion, hydrogel
source：期刊
specific source：ACS Appl. Mater. Interfaces, 2015, 7, 3003-3008
Issue time：2015年
An interpenetrating network (IPN) strategy has been widely facilitated to construct strong and tough hydrogels, but most of the efforts have been focused on organic/organic networks. Herein, aqueous dispersible 2,2′-(ethylenedioxy)-diethanethiol (EDDET) cross-linked graphene oxide (E-cGO) skeleton was in situ incorporated into a PVA matrix, resulting
in novel inorganic/organic IPN hydrogels with supermechanical and chondrocyte cell-adhesion properties. The unique interpenetrating structure and hydrogen bonding were
demonstrated to play critical roles in enhancing the compressive property of the IPN hydrogels, in comparison to the GO and thermally reduced graphene oxide (T-rGO) filled
hydrogels. It is critical that the E-cGO/PVA hydrogels have been demonstrated as being biocompatible, which make the E-cGO/PVA hydrogels promising candidate biomaterials for loadbearing biotissue substitution.