Opening the door: An artificial unimolecular transmembrane channel using pore-containing helical macromolecules is presented. The self-folding, shape-persistent helical macromolecules span the lipid bilayer, resulting in extraordinary channel stability and high transporting efficiency for protons and cations. The lifetime of this channel in the lipid bilayer membrane is impressively long, rivaling those of natural protein channels.
本研究工作利用中空螺旋高分子作為骨架實(shí)現(xiàn)了單分子跨膜通道的構(gòu)建。研究發(fā)現(xiàn)單分子跨膜通道在磷脂膜上非常穩(wěn)定（通道開(kāi)關(guān)達(dá)到20min以上），通道具有明顯的離子選擇性，能夠?qū)崿F(xiàn)從識(shí)別到物質(zhì)運(yùn)輸?shù)墓δ苓M(jìn)化。深入的研究工作將展開(kāi)，例如通道在膜上的排列模式與傳輸方向問(wèn)題、聚合物通道的單一化問(wèn)題等。感謝超分子結(jié)構(gòu)與材料國(guó)家重點(diǎn)實(shí)驗(yàn)室、國(guó)家自然科學(xué)基金（21274051，21574054等）對(duì)本工作的資助。
研究論文請(qǐng)參見(jiàn)：http://onlinelibrary.wiley.com/doi/10.1002/anie.201604071/full