[Polym Chem] Novel phthalocyanine and PEG-methacrylates based temperature-responsive polymers for targeted photodynamic therapy
作者：Jun Li, Weidong Zhang, Zhijun Hu, Xiong-Jie Jiang, To Ngai, Pui-Chi Lo, Wei Zhang, Gaojian Chen*
關(guān)鍵字：http://pubs.rsc.org/en/Content/ArticleLanding/2013/PY/c2py20668d#!divAbstract
論文來源：期刊
具體來源：Polym. Chem., 2013,4, 782-788
發(fā)表時間：2014年
A novel multi-targeting nanocarrier (SiPc-polymer) for photodynamic therapy (PDT) has been successfully polymerized via the incorporation of silicon(IV) phthalocyanine dichloride (SiPcCl2) to the thermoresponsive PEG-methacrylates based polymers. The resulting SiPc-polymer was characterized by1H NMR spectroscopy, GPC, UV-Vis and elemental analysis. The lower critical solution temperature (LCST) of the SiPc-polymer can be easily controlled via changing the ratio of the applied monomers, di(ethylene glycol) methyl ether methacrylate (DEGMEMA), oligo(ethylene glycol) methyl ether methacrylate (OEGMEMA, Mw= 475 g mol?1) and 2-hydroxyethyl methacrylate (HEMA). The synthesized polymers assemble into nanoparticles (70 nm) in aqueous solution, which normally exhibits permeation and retention (EPR)
effects, the thermo-responsive features provide the possibility to
selectively accumulate at a maligned tissue site upon mild heating and
high singlet oxygen quantum yields (ΦΔ= 0.55) are obtained which guarantee the controlled liberation of reactive oxygen species upon light irradiation. This provides a simple way to synthesize a multi-targeting drug carrier system for PDT.
