8. Synthesis and characterization of an amphiphilic graft polymer and its potential as a pH-sensitive drug carrier
writer：Yi Li , Hye Jung Heo , Guang Hui Gao , Seong Woo Kang , Cong Truc Huynh , Min Sang Kim , Jae W
keywords：H-sensitive Polymeric micelle Drug delivery
source：期刊
specific source：Polymer
Issue time：2011年
The synthesis and properties of a new pH-sensitive polymer Poly(3-caprolactone) Grafted Poly(ethylene
glycol) Based Poly(?-amino ester) (PEGAE-g-PCL) are described here. The successful synthesis of the graft
copolymer was confirmed by 1H NMR. The self-assemble behavior of the amphiphilic polymer was
investigated using pyrene as a probe. Dynamic light scattering (DLS) showed that the polymeric micelles
had a size of 60 nm at physiological pH and were responsive to pH. A spherical morphology was observed
for the micelles using transmission electron microscopy (TEM). Zeta-potential measurement at different
pH showed that the micelles were neutral at pH 7.4 and positively charged at lower pH. Doxorubicin
(DOX) was used as a model drug and loaded in the micelles. The drug loaded micelles showed a slow and
pH-dependant drug release behavior. The remaining hydroxyl groups on the main chain made it possible
the further conjugation of imaging agents or targeting groups.