Near-Infrared Light-Responsive and Separable Microneedles for Transdermal Drug Delivery of Metformin on Diabetic Rats
writer：Weijiang Yu, Guohua Jiang,* Yang Zhang, Depeng Liu, Bin Xu and Junyi Zhou
keywords：Transdermal delivery, microneedles, NIR
source：期刊
specific source：Journal of Materials Chemistry B, 2017, DOI: 10.1039/C7TB02236K
Issue time：2017年
Abstract: Near-infrared
light triggered and separable microneedles (MNs) have been fabricated by
separately molding method. The photothermal conversion agent(prussian blue nanoparticles,PB NPs)and hypoglycemic drug(metformin)have been embedded into
the separable polycaprolactone (PCL) MNs arrowheads.These MNs arrowheads arecapped on dissolving polyvinyl alcohol/polyvinyl
pyrrolidone (PVA/PVP) solid supporting substrate. The as-fabricated MNs
exhibited an excellent photothermal conversion properties under near-infrared
light (NIR) irradiation, causing the MNs arrowheads to melt due to the
photothermal conversion of PB NPs. After applied on skin, the separable MNs
arrowheads could be embedded in the skin due to the dissolving of supporting
substrate after absorbing the interstitial fluid. When the embeddedMNsarrowheads were exposed to NIR irradiation, the
MNs arrowheads undergone a rapid thermal ablation from a solid to a liquid
state, thus enabling the release of encapsulated metformin to be NIR modulated.
They allowed on-demand control of timing and dose of drug released. It suggests
the developed NIR-triggered and separable MNs are a promising transdermal drug
delivery system that enables the patient or physician to adjust therapy
precisely in an active manner, thus, improving treatment efficiency and
reducing side-effects.
