Fabrication of h-MnO2@PDA composite nanocarriers for enhancement of anticancer cell performance by photo-chemical synergetic therapies
writer：Xue-ya Zhang, Guo-hua Jiang*, Gao Song, Tian-qi Liu, Yan-fang Sun*, Zhi-yong Zeng
keywords：Nanocarriers, biomaterials, chemical therapy, chemo-dynamic therapy, photothermal therapy
source：期刊
specific source：Frontiers of Materials Science
Issue time：2021年
By in-situ growth of MnO2 on solid SiO2 nanoparticles (NPs) and then removal of SiO2 nuclei, highly dispersed hollow manganese dioxide (h-MnO2) with uniform morphology can be obtained. The obtained h-MnO2 is further used to load anticancer drug doxorubicin (DOX) and subsequently modified with biocompatible and biodegradable polydopamine (PDA), finally to form polydopamine-coated DOX/h-MnO2 nanocomposites (DOX/h-MnO2@PDA). Due to the photothermal of PDA, photodynamic performance of the h-MnO2, and chemical therapy effect of DOX, the obtained DOX/h-MnO2@PDA can be used to inhibit tumor cells via a photo-chemical synergetic therapy method.
