Electrospun porcine acellular dermal matrix and polycaprolactone composite nanofibrous scaffolds for accelerating wound healing
writer：Xiaofei Gao, Guohua Jiang, Liming Ruan, Yanfang Sun, Uladzislau E. Aharodnikau, Khaydar Yunusov, Ya
keywords：porcine acellular dermal matrix, 3D wound dressing, ε-polylysine, antibacterial, electrospun
source：期刊
specific source：Fibers and Polymers
Issue time：2022年
Electrospun nanofibers represent a novel class of scaffold materials that show great potential in wound healing owing to relatively large surface area, better mimicry of native extracellular matrix, adjustable waterproofness and breathability, and programmable drug delivery process. In this work, electrospun polycaprolactone (PCL) and porcine acellular dermal matrix (PADM) composite nanofibrous membranes have been developed by electrospinning technology and inflated into three-dimensional (3D) structural scaffold (PCL-PADM) by gas foaming method. The obtained PCL-PADM has higher thermal stability, hydrophilicity and better cell adhesion compared with PCL. In addition, ε-polylysine (ε-PL) is further attached onto the surface of PADM/PCL to offer its good antibacterial properties. Moreover, the PADM/PCL fibrous scaffolds show excellent cytocompatibility for promoting cell proliferation. In vivo models showed that the resultant PADM/PCL fibrous scaffolds exhibit an accelerating wound healing effect through promoting expression of vascular factor (CD31) and decreasing the expression of tumor necrosis factor-α (TNF-α). These results indicate that the 3D fibrous scaffolds may be a potential wound dressing for wound closure.