80. Preparation of Multi-responsive Micelles for Controlled Release of Insulin
writer：Guohua Jiang*, Tengteng Jiang, Hua Chen, Lei Li, Yongkun Liu, Huijie Zhou, Yu Feng, Jinhua Zhou
keywords：polymeric micelles; glucose-sensitivity; insulin; drug release
source：期刊
specific source：Colloid and Polymer Science
Issue time：2015年
The polymeric micelles were prepared by the copolymerization of poly (methoxypolyethylene glycol acrylamide)-macroinitiator (MePEGA) 3-acrylamide phemylboronic acid (APBA) and 2-nitrobenzyl acrylate (NBA) using a surfactant-free miniemulsion reversible addition fragmentation chain transfer (RAFT) polymerization method. The as-prepared micelles were characterized by 1H NMR, TEM and DLS. Due to the UV light and glucose-sensitivity of as-prepared micelles, the micelles could be used to encapsulate insulin. The insulin release properties of micelles under UV light irradiation and different glucose concentrations were investigated. The micelles exhibited relative lower cytotoxicity and excellent stability against protein solution. The loaded insulin remained the structure stability after release through CD spectra analysis. These results showed that the micelles are one of effective candidate carriers for insulin release.