78. Preparation of Multi-responsive Micelles from Functionalized Polysuccinimide for Drug Release
writer：Xiangxiang Du, Yongjie Yan, Guohua Jiang*
keywords：biomaterials; functionalization of polymers; micelles
source：期刊
specific source：Journal of Polymer Materials
Issue time：2014年
Multi-responsive graft copolymers with tertiary amine side groups (PSI-g-DEEDA-DDA) were designed and synthesized via ring-opening reactions of polysuccinimide (PSI) with N, N diethylethylenediamine (DEEDA) and dodecylamine (DDA). The as-prepared PSI-g-DEEDA-DDA could be further self-assemblied into polymeric micelles in aqueous solution due to the difference of water-solubility of side chains. The composition and structure of micelles have been investigated by hydrogen nuclear magnetic resonance spectroscopy (1H NMR), Fourier transform infrared spectroscopy (FT-IR), scanning electron microscope (SEM) and dynamic light scattering (DLS). A hydrophobic drug, indomethacin (IND), has been chosen as a model drug to investigate the drug release properties triggered by pH, temperature, and CO2. This work provided a new platform for development drug delivery vehicles with multi-responsive properties.