83. Preparation of dual- responsice nanohydrogels for controlled release of insulin
writer：Lei Li, Guohua Jiang*, Tengteng Jiang, Qin Huang, Hua Chen Yongkun Liu
keywords：Nanogels; pH-sensitivity; glucose-sensitivity; insulin; drug release
source：期刊
specific source：Journal of Polymer Materials
Issue time：2015年
The polymeric nanogels were prepared by the copolymerization of polyethylene glycol methyl acrylate (PEGMEM) and 3-acrylamide phemylboronic acid (AAPBA) using N, N-methylene bis acrylamide (BIS) as cross-linking agent. The as-prepared nanogels were characterized by 1H NMR, FT-IR, transmission electron microscopy (TEM), and dynamic light scattering (DLS). Due to the pH sensitivity and the glucose-sensitivity of as-prepared nanogels, the nanogels could be used to encapsulate insulin. The insulin release properties of nanogels under different pH and glucose concentrations were investigated. These results showed that the nanogels are one of effective candidate carriers for insulin release.