88. Photo-induced synthesis glucose-responsive carries for controlled release of insulin in vitro
writer：Xiangxiang Du, Guohua Jiang*, Lei Li, Yongkun Liu, Hua Chen, Qin Huang
keywords：Photo-polymerization; Glucose-sensitive; Insulin; Drug release
source：期刊
specific source：Colloid and Polymer Science, 2015, DOI: 10.1007/s00396-015-3625-5.
Issue time：2015年
The glucose-responsive amphiphilic poly(PEGMA-co-AAPBA) copolymer micelles as drug carriers have been developed using 3-phenylpyruvic acid (3-PPA) as photo-initiator. Under the light irradiation, 3-PPA could be self-polymerized into the trimer structure to execute the emulsifier and initiator functions that confirmed by Gas Chromatographic-Mass Spectrum (GC-MS) analysis. The structure and morphology of resultant poly(PEGMA-co-AAPBA) micelles were characterized by 1H NMR, and TEM. Insulin, as the model drug of diabetes, was loaded into micelles during the photo-polymerization process. The as-prepared polymeric micelles exhibited the excellent glucose-sensitivity. The loaded insulin could be released from micelles triggered by regulation of temperature and glucose concentration in the environment. The new drug carriers provided a potential application for the therapy diabetes based on glucose-sensitive controlled drug delivery systems.