由碩士研究生張駿豪等完成的研究論文“Red blood cellmembrane-camouflaged polydopamine and bioactived glass composite nanoformulation for combined chemo/chemodynamic/photothermal therapy”被《ACS Biomaterials Science and Engineering》錄用！
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Red blood cell membrane-camouflaged polydopamine and bioactived glass composite nanoformulation for combined chemo/chemodynamic/photothermal therapy
Junhao Zhang a,b, Yanfang Sun c,*, Luping Ren a,b, Lianxu Chen a,b, Lei Nie d, Admin Shavandi e, Khaydar E. Yunusov f, Uladzislau E. Aharodnikau g, Sergey O. Solomevich g, Guohua Jiang a,b,*
Abstract:Combinations of different therapeutic strategies, including chemotherapy (CT), chemodynamic therapy (CDT), and photothermal therapy (PTT), are needed to effectively address evolving drug resistance and the adverse effects of traditional cancer treatment. Herein, acamouflage composite nanoformulation (TCBG@PRs), an antitumour agent (tubercidin, Tub) loaded intoCu-doped bioactive glasses (CBGs) and subsequently camouflaged by polydopamine (PDA) and red blood cell membranes (RBCm), was successfully constructed for targeted and synergetic antitumour therapies bycombining CT of Tub, CDT of doped copper ions, and PTT of PDA. In addition, the TCBG@PR composite nanoformulation was camouflaged with a red blood cell membrane (RBCm) to improve biocompatibility, longer blood retention times, and excellent cellular uptake properties.It integrated with long circulation and multimodal synergistic treatment (CT, CDT, and PTT) with the benefit of RBCms to avoid immune clearance for efficient targeted delivery to tumor locations, producing an "all in one" nanoplatform.In vivo results showed that the TCBG@PR composite nanoformulation prolonged blood circulation and improved tumor accumulation. The combination of CT, CDT, and PTT therapies enhanced antitumour therapeutic activity, and light-triggered drug release reduced systematic toxicity and increases synergisticantitumor effects.
