由碩士研究生王若凡等完成的研究論文“Fabrication of curcumin-loaded silk fibroin and polyvinyl alcohol composite hydrogel films for skin wound healing”被《ACS Applied Bio Materials》錄用！
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Abstract: Skin regeneration of full-thickness wounds remains a challenge, requiring a well-regulated interplay of cell-cell and cell-matrix signaling. Herein the composite hydrogel films composed by silk fibroin (SF), polyvinyl alcohol (PVA) as scaffolds loaded with curcumin nanoparticles (Cur NPs) were developed for skin wound healing. The structure and physicochemical proeprties of hydrogel films were firstly evaluated by the scanning electron microscope (SEM), water contact angle, chemical, and mechanical measurements. In addition, the as-fabricated composite hydrogel films have an unique 3D structure and excellent biocompatibility that facilitates the adhesion and growth of cells. Antimicrobial tests in vitro showed that they could inhibit the growth of bacteria due to the incorporation of Cur NPs into composite hydrogel films. The efficacy of the curcumin-loaded SF/PVA composite hydrogel films for skin wound healing was investigated on the skin defect model in vivo. Immunological analysis showed that the as-fabricated Cur NPs loaded SF/PVA composite hydrogel films inhibited inflammation at the wound sites while promoting angiogenesis during the wound healing process.
Keywords: hydrogel film, wound dressings, silk fibroin, curcumin nanoparticles, antibacterial
