Rational design of flexible microneedle dressings coupled with CaO2@PDA-loaded nanofiber films for skin wound healing on diabetic rats
作者：Zhiyong Zeng, Guohua Jiang,* Yanfang Sun, Uladzislau E. Aharodnikau, Xiaofei Gao, Khaydar Yunusov, T
關鍵字：Microneedles
論文來源：期刊
具體來源：Biomaterials Science
發表時間：2022年
Skin ulcers is one of the complications of diabetes. At present, the treatment of diabetic skin wound is still not satisfactory, and the efficiency of drug delivery is limited by the depth of penetration. Herein, a synergistically flexible microneedle dressing is presented for effectively promoting diabetic wound healing. Metformin as anti-diabetic drug can be loaded into microneedles, which can be effectively pierced into the skin of diabetic rats to trigger a response for regulating the blood glucose levels. A novel multifunctional nanosystem CaO2@polydopamine (CaO2@PDA) is introduced into polycaprolactone and gelatin (PCL/Gel) electrospun nanofiber films as microneedle back patches to inhibit inflammation, provide oxygen, and absorb the excess exudate. Besides, the CaO2@PDA in back patches also can provide effective antibacterial properties against both of S. aureus and E. coli. Additionally, the as-fabricated flexible microneedle dressings loaded with metformin and CaO2@PDA nanoparticles demonstrate high level of CD31 and low level of TNF-α, leading to accelerate diabetic skin wound closure. These distinctive features demonstrate that our microneedle system can be a facile candidate for efficient wound healing in patients with diabetes and may be applied in various biomedical fields.
