108. Transdermal delivery of insulin with bioceramic composite microneedles fabricated by gelatin and hydroxyapatite
作者：Weijiang Yu, Guohua Jiang*, Depeng Liu, Lei Li, Hua Chen, Yongkun Liu, Qin Huang, Zaizai Tong, Jumin
關鍵字：Transdermal, insulin, microneedles
論文來源：期刊
具體來源：Materials Science and Engineering, C, 2017, 73, 425-428.
發表時間：2017年
Abstract: The organic-inorganic bioceramic composite microneedles (MNs) were prepared from hydroxyapatite (Hap) and gelatin (Gel) via a template method. The resultant hydroxyapatite and gelatin composite MNs exhibited low cytotoxicity and excellent mechanical properties. After transdermal administration to the diabetic rats, the insulin could be released from bioceramic composite MNs. An obvious and effective hypoglycemic effect could be obtained compared with that of subcutaneous injection route. This work suggests that bioceramic composite MNs containing of insulin have a potential application in diabetes treatment via transdermal ingestion.
