Oxidized regenerated cellulose-based hemostat with microscopically gradient Structure
writer：Y. Wu, J. He, W. Cheng, H. Gu, Z. Guo, S. Gao, Y. Huang
keywords：Oxidized regenerated cellulose, Controlled neutralization, Oxidized regenerated cellulose sodium, Hemostatic, Biodegradability
source：期刊
specific source：Carbohydrate Polymers
Issue time：2012年
Partially water-soluble oxidized regenerated cellulose carboxylate sodium (ORC-Na) materials have been prepared by controlled neutralizing oxidized generated cellulose (ORC). The carboxyl were converted into sodium carboxylate as evidenced by FT-IR, and carboxyl content decreased from 18.41% to 0.98%, with enhancing water solubility of ORC-Na to form gel, and SEM–EDX revealed that the sodium carboxylate groups presented in a gradient distribution from the exterior to the interior of fiber. ORC-Na introduced a new hemostatic mechanism, i.e., forming gel to mechanically seal off the crevasses of vessels. Due to its excellent water solubility and 5.23% carboxyl, ORC-Na-3 possessed optimum hemostatic efficiency and demonstrated a capability to stop bleeding within shortest time (102 and 138 s) with the least blood loss (0.886 and 1.006 g), and implantation test showed ORC-Na-3 could be absorbed in less than 2 weeks with no pathological response remaining. In conclusion, ORC-Na-3 is an efficient hemostat with optimum biodegradability.