Design of Phosphorus Ligands with Deep Chiral Pockets: Practical Synthesis of Chiral β-Arylamines by Asymmetric Hydrogenation.
writer：Guodu Liu, Xiangqian Liu, Zhihua Cai, Guangjun Jiao, Guangqing Xu, Wenjun Tang.*
keywords：Asymmetric Hydrogenation
source：期刊
specific source：Angew. Chem. Int. Edit. 2013, 52, 4235–4238. (DOI: 10.1002/anie.201300646, communication, IF = 12.25
Issue time：2013年
WingPhos, a C2‐symmetric bisphosphorus ligand with a deep and well‐defined chiral pocket was developed. It has shown high efficiency in the rhodium‐catalyzed asymmetric hydrogenation of (E)‐β‐aryl‐N‐acetyl enamides, cyclic β‐aryl enamides, and heterocyclic β‐aryl enamides. A series of chiral β‐arylisopropylamines, 2‐aminotetralines, and 3‐aminochromans can be synthesized with excellent ee values (nbd=3,5‐norbornadiene; TON=turnover number).