Polyphenol scaffolds in tissue engineering
writer：Zhang X, Li Z, Yang P, Duan G, Liu X, Gu Z*, Li Y*
keywords：Polyphenol scaffolds, tissue engineering
source：期刊
specific source：DOI: 10.1039/d0mh01317j
Issue time：2020年
Polyphenols are a class of ubiquitous compounds distributed in nature, with fascinating inherentbiocompatible, bioadhesive, antioxidant, and antibacterial properties. The unique polyphenolic structuresbased on catechol or pyrogallol moieties allow for strong non-covalent interactions (e.g., multiplehydrogen bonding, electrostatic, and cation–Π interactions) as well as covalent interactions (e.g., Michaeladdition/Schiff-base reaction, radical coupling reaction, and dynamic coordination interactions withboronate or metal ions). This review article provides an overview of the polyphenol-based scaffoldsincluding the hydrogels, films, and nanofibers that have emerged from chemical and functionalsignatures during the past years. A full description of the structure–function relationships in terms of their utilization in wound healing, bone regeneration, and electroactive tissue engineering isalso carefully discussed, which may pave the path towards the rational design and facile preparation ofnext-generation polyphenol scaffolds for tissue engineering applications