A Smart H2O2-Responsive Drug Delivery System Made by Halloysite Nanotubes and Carbohydrate Polymers
writer：[2] Feng Liu, Libin Bai, Hailei Zhang,* Hongzan Song, Liandong Hu, Yonggang Wu,* and Xinwu Ba.
keywords：halloysite nanotubes, hydrogel, H2O2-responsiveness, drug delivery, initial burst release
source：期刊
specific source：ACS Applied Materials & Interfaces
Issue time：2017年
A novel chemical hydrogel was facilely achieved by coupling 1,4-phenylenebisdiboronic acid-modified halloysite nanotubes (HNTs-BO) with compressible starch. The modified HNTs and prepared hydrogel were characterized by solid-state nuclear magnetic resonance (NMR), Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM) and transmission electron microscope (TEM). The linkage of B-C in the hydrogel can be degraded into B-OH and C-OH units in the presence of H2O2, and result into the degradation of the chemical hydrogel. Pentoxifylline was loaded into the lumen of HNTs-BO and then give the pentoxifylline-loaded hydrogel. Drug release profile shows that it was no more than 7% dissolved when using PBS solution as release medium. Notably, a completely released (near 90%) can be achieved with the addition of H2O2 ([H2O2] =1×10-4 M), suggesting a high H2O2-responsiveness of as-formed hydrogel. The drug release results also show that the “initial burst release” can be effectively suppressed by loading pentoxifylline inside the lumen of HNTs than embedding the drug in hydrogel network. The drug-loaded hydrogel with H2O2-responsive release behaviour may open up a broader application in the field of biomedicine.