Cooperative Hierarchical Self-Assembly of Peptide Dendrimersand Linear Polypeptides into Nanoarchitectures MimickingViral Capsids
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specific source：Angew. Chem. Int. Ed. 2012, 51, 3130 –3133
Issue time：2012年
We have successfully demonstrated a versatile strategy for cooperative self-assembly of globular poly(llysine) dendrimers with linear poly(l-leucine). After a twostep hierarchical self-assembly, the nanoparticles possessed a capsid-like biomimetic nanoarchitecture. The hierarchical peptidesomes exhibited high gene-transfection efficiency as nonviral gene vectors. The strategy of the hierarchical selfassembly could also be applied for fabricating versatile nanoarchitectures. A detailed study of the cooperative selfassembly,
such as precise regulation of the morphology and medical applications, is being explored and will be reported in our future publications.