Stabilization of pH-Sensitive mPEG-PH-PLA Nanoparticles via Stereocomplexation between Enantiomeric Polylactides
writer：Rong Liu, Bin He*, Dong Li, Yusi Lai, James Z. Tang, Zhongwei Gu*
keywords：Stereocomplexation, Enantiomeric Polylactides
source：期刊
specific source：Macromol. Rapid Comm., 2012, 33(12): 1061-1066
Issue time：2012年
Methoxy poly(ethylene glycol)–poly( L -histidine)–poly(lactide) (mPEG 45 –PH 30 –PLA 82 ) triblock copolymers self-assemble into nanoparticles by sterocomplexation. The properties of the stereocomplex nanoparticles including morphology, stability, and biocompatibility are investigated. The results reveal that the stereocomplexation
between PLLA and PDLA segments could prevent the aggregation of the nanoparticles when the pH value is around 6.8. The mean diameter of the stereocomplex nanoparticles is stabilized at about 100 nm when the pH values are changed from 7.9 to 5.0. The cytotoxicity of the stereocomplex nanoparticles is evaluated, and the results demonstrate that the stereocomplexation could decrease the cytotoxicity of the PDLA segments.