Journal of the American Chemical Society. 2002, 124, 14834-14835
writer：Lang, Meidong; Grzesiak, Adam L; and Matzger, Adam J
keywords：para-hydroxyacetanilide; orthorhombic form; paracetamol; acetaminophen; nucleation
source：期刊
Issue time：2002年
A method for the production of crystalline polymorphs from solution is described which utilizes a diverse set of polymer heteronuclei. Application to crystalline polymorph selection for the important pharmaceuticals acetaminophen and carbamazepine is demonstrated. This method provides a new paradigm for polymorph selection, where solvent and temperature conditions can be chosen on the basis of process considerations and the polymer heteronucleus can be varied for specific polymorph production.