Mesoporous Silica Nanoparticles End-Capped with Collagen: Redox-Responsive Nanoreservoirs for Targeted Drug Delivery
writer：Zhong Luo, Kaiyong Cai, Yan Hu, Li Zhao, Peng Liu, Lin Duan, and Weihu Yang
keywords：controlled release; disulfides; drug delivery; nanoparticles; redox chemistry
source：期刊
specific source：ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 卷: 50 期: 3 頁: 640-643 DOI: 10.1002/anie.201005061 出
Issue time：2011年
Attachment of collagen (Col) to silica nanoparticles (MSN) by a disulfide linker, followed by introduction of lactobionic acid (LA, a cell-specific targeting moiety), results in a redox-responsive system for cell-specific intracellular drug delivery and efficient endocytosis (see picture). Controlled release of a model drug (fluorescein isothiocyanate, FITC) was achieved by cleavage of the disufide bonds.