Elliptical Polymer Brush Ring Array Mediated Protein Patterning and Cell Adhesion on Patterned Protein Surfaces.
writer：3) Wendong Liu, Yunfeng Li, Tieqiang Wang, Daowei Li, Liping Fang, Shoujun Zhu,Huaizhong Shen, Junhu
keywords：polymer brush, protein patterns, elliptical ring arrays, cell adhesion
source：期刊
specific source：ACS Appl. Mater. Interfaces 2013, 5, 12587?12593
Issue time：2013年
This paper presents a novel method to fabricate
elliptical ring arrays of proteins. The protein arrays are
prepared by covalently grafting proteins to the polymer brush
ring arrays which are prepared by the techniques combining
colloidal lithography dewetting and surface initiated atom-
transfer radical polymerization (SI-ATRP). Through this
method, the parameters of protein patterns, such as height,
wall thickness, periods, and distances between two elliptical
rings, can be ?nely regulated. In addition, the sample which
contains the elliptical protein ring arrays can be prepared over a large area up to 1 cm2, and the protein on the ring maintains its
biological activity. The as-prepared ring and elliptical ring arrays (ERAs) of ?bronectin can promote cell adhesion and may have
an active e?ect on the formation of the actin cytoskeleton.