【Acta Polymerica Sinica】Progress in Photo-initiated Living Graft Polymerization of Biomaterials
writer：Sun Liwei, Song Lingjie, Luan Shifang*, Yin Jinghua.
keywords：Photo-initiated living graft polymerization,Surface modification
source：期刊
specific source：Acta Polymerica Sinica
Issue time：2021年
Abstract：
Surface modification of biomaterials via graft polymerization has become one of the most important methods to enhance their virtual bio-functionalities. Compared with other living graft polymerization methods, photo-initiated living graft polymerization exhibits superior merits and has been more and more widely used in surface modification of biomaterials. The photoinitiators used for photo-initiated living graft polymerization are mainly categorized into three types: photoiniferter-mediated polymerization (PIMP), benzophenone and its derivatives, and thioxanthones. In this review, the development, graft mechanism and characteristics of the three photo-initiated living graft polymerization systems are briefly introduced. Meanwhile, the applications of photo-initiated graft polymerization in three different biomedical fields are mainly reviewed. i) Antibacterial surface: layered functional polymer brushes constructed by photo-initiated living graft polymerization have been developed to achieve antibacterial function on demand; ii) Immunoassay: layered functional polymer brushes can solve the problem of low detection sensitivity and protein interference; iii) Bioactive molecules fixed on the surface: visible light living graft polymerization system is used to realize the immobilized enzyme on the surface as well as the cell surface modification to improve the stability. Finally, their recent advances in the biomedical fields and the future opportunities and challenges are highlighted.