【Colloids and Surfaces B: Biointerfaces】Facile fabrication of bactericidal and antifouling switchable chitosan wound dressing through a ‘click’-type interfacial reaction
writer：Xianghong Wang, Shuaishuai Yuan, Yu Guo, Dean Shi*, Shifang Luan*, et al.,
keywords：Chitosan, Azlactone-carboxybetaine ester copolymer, Bactericidal, Antifouling
source：期刊
specific source：Colloids and Surfaces B: Biointerfaces, 2015, 136, 7-13
Issue time：2015年
Abstract:
A facile approach to functionalize chitosan (CS) non-woven surface with the bactericidal and antifouling switchable moieties is presented. Azlactone-cationic carboxybetaine ester copolymer was firstly prepared, then chemically attached onto CS non-woven surface through the fast and efficient ‘click’-type interfacial reaction between CS primary amines and azlactone moieties. The CS non-woven surface functionalized with cationic carboxybetaine esters is able to kill bacteria effectively. Upon the hydrolysis of carboxybetaine esters into zwitterionic groups, the resulting zwitterionic surface can further prevent the attachment of proteins, platelets, erythrocytes and bacteria. This CS non-woven that switches from bactericidal performance during storage to antifouling property before its service has great potential in wound dressing applications.