【ACS Applied Materials & Interfaces】Nuclease-functionalized poly(styrene-b-isobutylene-b-styrene) surface with anti-infection and tissue integration bifunctions
writer：Shuaishuai Yuan, Shifang Luan*, Shunjie Yan, Wanling Zheng, Jinghua Yin*, et al.,
keywords：poly(styrene-b-isobutylene-b-styrene) (SIBS), deoxyribonuclease (DNase), ribonuclease (RNase), antibacterial, cell adhesion
source：期刊
specific source：ACS Applied Materials & Interfaces, 2014, 6, 18078-18086
Issue time：2014年
Abstract:
Hydrophobic thermoplastic elastomers, e.g., poly(styrene-b-isobutylene-b-styrene) (SIBS), have found various in vivo biomedical applications. It has long been recognized that biomaterials can be adversely affected by bacterial contamination and clinical infection. However, inhibiting bacterial colonization while simultaneously preserving or enhancing tissue-cell/material interactions is a great challenge. Herein, SIBS substrates were functionalized with nucleases under mild conditions, through polycarboxylate grafts as intermediate. It was demonstrated that the nucleasemodified SIBS could effectively prevent bacterial adhesion and biofilm formation. Cell adhesion assays confirmed that nuclease coatings generally had no negative effects on L929 cell adhesion, compared with the virgin SIBS reference. Therefore, the as-reported nuclease coating may present a promising approach to inhibit bacterial infection, while preserving tissue-cell integration on polymeric biomaterials.