【Advanced Healthcare Materials】Low-Temperature Printed Hierarchically Porous Induced-Biomineralization Polyaryletherketone Scaffold for Bone Tissue Engineering(IF=11.09，中科院一區)
作者：Gao Xinshuai， Wang Honghua， Luan Shifang， Zhou Guangyuan
關鍵字：3D printing，biomineralization
論文來源：期刊
發表時間：2022年
Abstract：
Polyetheretherketone (PEEK) as a popular orthopaedic implant is usually fabricated to hierarchically porous structure for improving osteogenic activity. However, the applications are limited due to the excessively high processing temperature and uncontrollably tedious modification routes. Here, an amorphous polyaryletherketone with carboxyl groups (PAEK-COOH) is synthesized, and fabricated to the hierarchically controllable porous scaffolds via low-temperature 3D-printing process. The prepared PAEK-COOH scaffolds present controllable porous structures ranging from nano- to micro-scale, and their mechanical strengths are comparable to that of trabecular bone. More importantly, the in vitro experiments show that the nanoporous surface is conducive to promote cellular adhesion, and carboxyl groups can induce hydroxyapatite mineralization via electrostatic interaction. The in vivo experiments demonstrate that the PAEK-COOH scaffolds offer much better osseointegration without additional active ingredients, compared to that of PEEK. Therefore, this work will not only develop a promising candidate for bone tissue engineering, but provide a viable method to design PAEK biomaterials. This article is protected by copyright. All rights reserved