【Nature Communications】Tunable backbone-degradable robust tissue adhesives via in situ radical ring-opening polymerization(自然子刊)
作者：Ran Yang, Xu Zhang, Binggang Chen*, Qiuyan Yan*, Jinghua Yin, Shifang Luan.
關(guān)鍵字：adhesives，radical ring-opening polymerization
論文來源：期刊
具體來源：Nature Communications
發(fā)表時(shí)間：2023年
Abstract：
Adhesives with both robust adhesion and tunable degradability are clinically and ecologically vital, but their fabrication remains a formidable challenge. Here we propose an in situ radical ring-opening polymerization (rROP) strategy to design a backbone-degradable robust adhesive (BDRA) in physiological environment. The hydrophobic cyclic ketene acetal and hydrophilic acrylate monomer mixture of the BDRA precursor allows it to effectively wet and penetrate substrates, subsequently forming a deep covalently interpenetrating network with a degradable backbone via redox-initiated in situ rROP. The resulting BDRAs show good adhesion strength on diverse materials and tissues (e.g., wet bone >16 MPa, and porcine skin >150 kPa), higher than that of commercial cyanoacrylate superglue (~4 MPa and 56 kPa). Moreover, the BDRAs have enhanced tunable degradability, mechanical modulus (100 kPa-10 GPa) and setting time (seconds-hours), and have good biocompatibility in vitro and in vivo. This family of BDRAs expands the scope of medical adhesive applications and offers an easy and environmentally friendly approach for engineering.