【International Journal of Biological Macromolecules】Bionic Double-crosslinked Hydrogel of poly (γ-glutamic acid)/poly (N-(2-hydroxyethyl) acrylamide) with Ultrafast Gelling Process and Ultrahigh Burst Pressure for Emergency Rescue（IF=8.2,中科院一區）
作者：Tingwu Liu, Wen Sun, Changjun Mu, Xu Zhang, Donghua Xu, Qiuyan Yan* and Shifang Luan*.
關鍵字：Double-crosslinked; Ultrafast gelling process; Ultrahigh burst pressure tolerance
論文來源：期刊
具體來源：International Journal of Biological Macromolecules
發表時間：2024年
Abstract:
Injectable adhesive hydrogels combining rapid gelling with robust adhesion to wet tissues are highly required for fast hemostasis in surgical and major trauma scenarios. Inspired by the cross-linking mechanism of mussel adhesion proteins, we developed a bionic double-crosslinked (BDC) hydrogel of poly (γ-glutamic acid) (PGA)/poly (N-(2-hydroxyethyl) acrylamide) (PHEA) fabricated through a combination of photo-initiated radical polymerization and hydrogen bonding cross-linking. The BDC hydrogel exhibited an ultrafast gelling process within 1 s. Its maximum adhesion strength to wet porcine skin reached 254.5 kPa (9 times higher than that of cyanoacrylate (CA) glue) and could withstand an ultrahigh burst pressure of 626.4 mmHg (24 times higher than that of CA glue). Notably, the BDC hydrogel could stop bleeding within 10 s from a rat liver incision 10 mm long and 5 mm deep. The wound treated with the BDC hydrogel healed faster than the control groups, underlining the potential for emergency rescue and wound care scenarios.