Star-shaped polymer consisting of a porphyrin core and poly(L-lysine) dendron arms: synthesis, drug delivery and in vitro chemo/photodynamic therapy
writer：[1] Dong Ma, Zong-Hua Liu, Qian-Qian Zheng, Xiao-Yan Zhou, Yi Zhang, Yun-Feng Shi, Jian-Tao Lin, Wei
keywords：star polymer, porphyrin, chemo/photodynamic therapy
source：期刊
specific source：Macromolecular Rapid Communications
Issue time：2013年
A novel star-shaped polymer, porphyrin-poly(L-lysine) dendrons (PP-PLLD), is synthesized by
the click reaction between azido-modifi ed porphyrin and propargyl focal point poly(L-lysine)
dendrons. Its chemical structure is characterized by 1 H nuclear magnetic resonance, Fourier
transform infrared spectroscopy, and gel permeation chromatography (GPC) is analyses etc.
Due to its amphiphilic property, the obtained PP-PLLD has a low critical micelle concentration
in an aqueous solution, and can load doxorubicin (DOX) with
a loading amount of 64 μ g mg ? 1 . By in vitro toxicity assay,
PP-PLLD has no dark cytotoxicity but has signifi cant phototoxicity.
Moreover, DOX-loaded PP-PLLD shows a higher cytotoxicity
under the light condition than PP-PLLD or DOX alone,
suggesting PP-PLLD has a potential application in combined
photodynamic therapy and chemotherapy.