国内精品国产三级国产在线专_欧美日韩在线播放一区二区_成人xxxx视频_欧美激情视频一区_色女人综合av_久久久亚洲影院_久久久久久九九_成人免费网站在线_日韩美女毛茸茸_狠狠干一区二区

Cellulose membrane has been widely used for bioseparation and blood puri?cation but suffers from fouling issue and insuf?cient biocompatibility. Surface grafting of zwitterions onto membrane surface can effectively alleviate this issue. Current grafting methods are mostly based on free radical polymerizations and have limitations of multi-step process, the requirement of inert atmosphere and inevitable ?ux decline. Herein we put forward a simple method for cellulose membrane (CM) zwitterionization. The modi?cation was carried out via a one-step method based on the alkoxysilane condensation reaction using three silane coupling agents including (3-carboxypropylbetaine-propyl)-trimethoxysilane(CPPT),(3-sulfopropylbetaine-propyl)-trimethoxysilane (SPPT), and (3-sulfobutylbetaine-propyl)-trimethoxysilane (SBPT). Membrane surfaces were characterized by ATR-FTIR, XPS, SEM, water contact angle (WCA) and streaming potential. Membrane mechanical performance, pore size and its distributions were measured. The antifouling property, hemocompatibility and cytocompatibility of the membranes were evaluated by protein adsorption, platelet adhesion, cell attachment and MTT assay experiments. The results show that sulfobetaines and carboxybetaines were successfully grafted on the CM surface. The obtained zwitterions-grafted membranes show excellent resistance to protein adhesion, platelet adhesion and cell attachment. More importantly, the biocompatibility of the CM membrane was retained.