Abstract：The pervasive wearable electronic devices are driving sensor innovation towards increased diversity and multifunctionality, to meet the needs of complex and varied environments. The accuracy of wearable sensors in detecting and feedback on stress is typically contingent upon the responsiveness of material structures, which can be easily perturbed by environmental humidity. In this study, one with excellent hydrophobicity and moisture resistance was developed, thereby effectively suppressing the electrostatic shielding effect caused by water ionization, while retaining the inherent ability of the material surface to generate and capture charges. In high-humidity environments (98% RH), the self-powered sensor exhibited a full scale output retention rate of over 82.4%, thus overcoming the limitations of sensor application in such conditions. This study provides new insight into high-performance sensing that is resistant to environmental interference, which is of great significance for the development and design of electronic skin, wearable electronic devices, and soft robotics.