Title: Electrictive nano-composite polymer: preparation and experimental study on the biological activity
Abstract:
Three-dimensional scaffold is the core of the establishment cells and organisms in bone tissue engineering,In order to make it more suitable for clinical bone repair needs,We had preliminary studied biological activity of op-HA and PLGA in degradation characteristics of the combination of polymer materials to improve the biocompatibility and osteoinductive capacity. With the development of technology, conductive polymer is currently being further studied.They have unique electrochemical and physical properties and the potential use of biological medicine including in biosensors,neural probes,drug release regulator,initiator and self-oxidants. Copolymer were consisted of Aniline oligomer and the aliphatic polyester.They were characterized by conductivity, biodegradability, biocompatibility. In this paper,the conductive material with the PAP and the op-HA composites were prepared by blending PLGA.In two and three dimensional structure was characterized by instrument testing,cell culture, animal experiments.By means of its physical and chemical properties,mechanical properties,biocompatibility and evaluation of bone ability can observe the content of materials with different conductivity in tissue engineering feasibility study. Proportion of the PAP to find the best content, provide the basis for clinical application.
Conclusion:
Low content of electroactive polymer nano-composite bone repair PAP/op- HA/PLGA have good biocompatibility,osteoblast adhesion,proliferation and osteogenic gene expression of related to bone repair,by the bone defect experiment and the role of the pulse electrical stimulation,the material reflects a good performance.
Key words:
Nano-hydroxyapatite, Poly (lactide-co-glycolide), Polyaniline, Conducting polymer, Composite, Tissue engineering scaffold, Biocompatibility, Electrical stimulation, Bone repair, Freeze-drying.