A Bioorthogonal Approach for the Preparation of a Titanium-Binding Insulin-like Growth-Factor-1 Derivative by using Tyrosinase
writer：Chen Zhang,Hideyuki Miyatake,Yu Wang,Takehiko Inaba,Yi Wang,Peibiao Zhang,Yoshihiro Ito
keywords：胰島素樣生長因子（IGF-1 ），粘附蛋白，
source：期刊
specific source：Angew. Chem. Int. Ed. 2016, 55: 1-6，DOI: 10.1002/anie.201603155
Issue time：2016年
Enhanced cell growth occurs on a titanium surface modified with insulin-like growth-factor-1 prepared by a bioorthogonal approach combining protein engineering and enzyme modification, as shown by Y. Ito and co-workers in their Communication (10.1002/anie.201603155). The picture shows a peptide sequence (center), which is inspired by an underwater adhesion protein (represented as a strong man) secreted by mussels, binding to a dental implant?(right) representing titanium-based medical devices, and to a growth factor stimulating a cell through the receptor?(left).
