L3MBTL1 Recognition of Mono- and Dimethylated Histones, Nature Structural & Molecular Biology, 14, 1229-1230 (2007).
Crystal structures of the L3MBTL1 MBT repeats in complex with histone H4 peptides dimethylated on Lys20 (H4K20me2) show that only the second of the three MBT repeats can bind mono- and dimethylated histone peptides. Its binding pocket
has similarities to that of 53BP1 and is able to recognize thedegree of histone lysine methylation. An unexpected mode of peptide-mediated dimerization suggests a possible mechanism for chromatin compaction by L3MBTL1.