作者：張黎明等 // Zhang, L. M.; et al
關(guān)鍵字：天然大分子，生物大分子, 功能材料, 雜化材料 // Natural macromolecules, Biomacromolecules, Functional materials, Hybrid materials
論文來(lái)源：期刊
發(fā)表時(shí)間：2026年
*Corresponding author(s)/通訊作者. #These authors contributed equally to this work/共同第一作者.
[384] Yang, H. K.; Zhang, L. M. * Preparation, self-assembly, loading drug, blood clotting and hemolysis of amphiphilic diblock copolymers based on α-alkyne poly(ε-benzyloxycarbonyl-L-lysine) and α-azido heparin. Colloids and Surfaces A-Physicochemical and Engineering Aspects, 2026, incomplete submission.
[383] Deng, J. J.#; Chen, S. S.#.; Li, N.#; Zhou, J. Y.; Lao, G. J.; Ren, M.; Yang, C.; Yan, L.*; Zhang, L. M.*Amphiphilic beta-cyclodextrin-centered heteroarm star polymers toward the co-delivery of methotrexate and plasmid DNA. Journal of Biomaterials Science, Polymer Edition, 2026, incomplete submission.
[382] Zhang, J. Z. #; Liang, H. S. #; Mao, X. H.; Wang, F.*; Huang, L. L.*; Zhang, L. M.* Gene delivery therapy and photothermal therapy of osteosarcoma via multifunctional spermine-modified amylose@IR-780 nanocomplexes. Biomacromolecules, 2026, incomplete submission.
[381] Wang, H. Z.; Lu, B.; Zhou, J. Y.; Xia, H. J.; Guo, S.-Z.*; Zhang, L. M.* From Jenga-style to Wound Repair: Structural and Therapeutic Potential of a Gas-Releasing, pH/Glucose-Responsive Biomass Hydrogel. Acta Biomaterialia, 2026, Confirming your submission.
[380] Lu, B.; Zhou, J. Y.; Wang, H. Z.; Lai, J. Y.; Zheng, X.; Guo, S.-Z.*; Zhang, L. M.* Intelligent ROS-Triggered NO and Isotretinoin Co-Delivery Hydrogel Dressings for Microenvironment Modulation and Rapid Repair of Diabetic Wounds. Chemical Engineering Journal, 2026, In Revision.
[379] Zheng, X.; Zhou, J. Y.; Wang, H. Z.; Lu, B.; Lai, J. Y.; Guo, S.-Z.*; Zhang, L. M.* Dual-Modality Cancer Therapy via Light-Triggered CO Release and Photothermal Effects from Engineered Prussian Blue Nanoparticles. Small, 2026, Confirming your submission.
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[學(xué)術(shù)會(huì)議/Scientific Conferences-160] 陸濱，王含章，郭雙壯*，張黎明*. 新型智能水凝膠用于糖尿病傷口 (墻報(bào)). 中國(guó)化學(xué)會(huì)第35屆學(xué)術(shù)年會(huì), 2026年4月11日至14日在重慶市舉行，4月10日?qǐng)?bào)到。 https://www.chemsoc.org.cn/meeting/35th/
摘要：糖尿病慢性創(chuàng)面因長(zhǎng)期炎癥反應(yīng)、細(xì)菌感染以及組織再生能力受損而難以愈合，仍是亟待解決的臨床問(wèn)題。本研究構(gòu)建了一種活性氧響應(yīng)型一氧化氮釋放水凝膠體系，以三羥甲基氨基甲烷改性的透明質(zhì)酸為基體，引入具有天然抗菌活性的 ε-聚賴(lài)氨酸，并結(jié)合功能化中空介孔雜化二氧化硅納米顆粒，實(shí)現(xiàn)藥物負(fù)載與刺激響應(yīng)釋放。該水凝膠可在溫和條件下快速凝膠化，形成穩(wěn)定三維網(wǎng)絡(luò)結(jié)構(gòu)，表現(xiàn)出良好的組織黏附性能、抗菌活性及促愈合潛能。通過(guò)結(jié)構(gòu)與功能模塊的理性設(shè)計(jì)，材料在氧化應(yīng)激條件下可實(shí)現(xiàn)異維A酸的可控釋放，并進(jìn)一步觸發(fā)按需 NO 生成。體內(nèi)外實(shí)驗(yàn)表明，異維A酸與 NO 的釋放均呈 ROS 水平依賴(lài)性且具可調(diào)控特征，從而顯著促進(jìn)創(chuàng)面閉合，增強(qiáng)膠原沉積與血管新生，并改善局部炎癥微環(huán)境。該水凝膠體系具有良好的生物相容性與智能響應(yīng)特性，提示其作為多功能創(chuàng)面敷料在糖尿病慢性創(chuàng)面高效治療中具有潛在應(yīng)用價(jià)值。