NIR-I-to-NIR-II fluorescent nanomaterials for biomedical imaging and cancer therapy,Journal of Materials Chemistry B, 2018, 6, 349
writer：Jingya Zhao, Dian Zhong and Shaobing Zhou
keywords：Near-infrared (NIR) fluorescence
source：期刊
specific source：Journal of Materials Chemistry B, 2018, 6, 349
Issue time：2018年
Near-infrared (NIR) fluorescence imaging, which affords high imaging resolution owing to deep tissue
penetration of NIR photons, is an attractive imaging modality for both biomedical research and clinical
applications. To further improve the image contrast at increased tissue depth, recently much attention
has been focused on the development of NIR-I-to-NIR-II fluorescence imaging, which can remarkably
reduce the interference from photon absorption, scattering and tissue autofluorescence with excitation
in the 700–950 nm NIR-I window and emission in the 1000–1700 nm NIR-II window. In this review,
we highlight recently developed NIR-I-to-NIR-II fluorescent nanomaterials, including silver chalcogenide
quantum dots, single-walled carbon nanotubes and polymer nanoparticles. We discuss the advantages
of these nanomaterials as fluorescent tags in deep tissue imaging by comparing them with conventional
fluorophores, and then survey the implementation of NIR fluorescence imaging with these
nanomaterials, including instrumentation, data analysis and surface biofunctionalization of the
nanomaterials. Finally, we discuss recent applications of NIR-I-to-NIR-II fluorescent nanomaterials in the
biomedical imaging field, with an emphasis on how to use them to achieve simultaneous cancer
diagnosis and therapy.