Dynamic Hybrid Colloidosomes via Electrostatic Interactions for pH-Balanced Low Premature Leakage and Ultrafast Cargo Release
writer：Ting Guo
keywords：Colloidosomes
source：期刊
specific source：Nano Lett. 2019, 19(9), 6065-6071.
Issue time：2019年
trade-off between minimized premature
leakage and rapid cargo release on demand is an intractable
obstacle faced by smart delivery systems that restrains them
from lab to market. To address this dilemma, dynamic hybrid
colloidosomes relying on strong yet reversible electrostatic
interactions are developed, simply through one-pot cooperative
self-assembly of silica nanoparticles and fluorescent
carbon dots at the interface of emulsion droplets. Specifically,
pH-driven charge reversal of zwitterionic carbon dots leads to
immediate electrostatic conversion between the two building blocks from attraction to repulsion. This makes robust locking and
instantaneous breakdown of the colloidosomes subtly balanced, thus enabling low off-state leakage (10.5% over 7 days) while
ultrafast on-state release (>90% within 5 min) upon an acidic stimulus. We envision that such biocompatible, traceable, and
smart colloidosomes will offer unique opportunities for broad applications as on-demand release is desired.