Preparation and Characterization of BiodegradableElectrospun Polyanhydride Nano/Microfibers
writer：Qiuxiang Su, Aijun Zhao, Hongsen Peng, and Shaobing Zhou?
keywords：Polyanhydride, X-ray Diffraction, Ultrafine, Fibers, Degradation.
source：期刊
specific source：J. Nanosci. Nanotechnol. 2010, Vol. 10, No. xx
Issue time：2010年
The biodegradable polyanhydride copolymers P(CPP–SA) composed of p-carboxyhenoxy propane
(CPP) and sebacic acid (SA) at weight ratios of 20:80, 35:65 and 50:50 were polymerized by a melt
polycondensation process without catalyst. The copolymers were characterized by fourier transform
infrared spectroscopy (FT-IR), 1H-nuclear magnetic resonance (1H-NMR), Ubbelohde viscometer,
differential scanning calorimetry (DSC) and wide angle X-ray powder-diffraction (XRD). P(CPP–SA)
nano/microfibers were the first time to be fabricated by electrospinning. The copolymers hold an
excellent fibre-forming performance and the diameter range of 80–3,200 nm can be obtained. The
in vitro degradation of the polyanhydride copolymers was evaluated in form of the nano/microfibers
by investigating the change of fibrous morphology, weight loss and pH change of degradation
medium. The experimental results showed that degradation rate was fast in the fist day and slow in
the following period, furthermore the degradation rate decreased with the increase of the content
of CPP in copolymers. Therefore, the electrospun polyanhydride nano/microfibers exhibited strong
potential as drug delivery vehicle and tissue engineering scaffold.